DegronMD

Uniprot ID: Q7Z460

Source protein: CLIP-associating protein 1

Source gene: CLASP1

Class: DEG_SPOP_SBC_1

Location: 793:797

E3 ligase: SPOP

DEGRON score: 0.9931

ASA_SCORE: 63.12

COIL: 0.705

CONS_SCORE: 0.246

DSS_SCORE: 0.3474

HELIX: 0.1144

FCONS_SCORE: 0.9098

RIG_SCORE: 0.7766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A807V	TCGA-AA-3977	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	0.0556
p.P785L	TCGA-CW-5580	KIRC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1111
p.R786K	DO222656	BTCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1389
p.A799V	DO7828	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	0.2778
p.E789Q	DO222705	ESCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.2222
p.Y788C	DO233748	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.D802N	DO14566	HNSC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.A803S	DO26949	LUSC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1667
p.P790S	DO51766	STAD	ICGC	VLSTS	DEG_SPOP_SBC_1	0.25
p.P790S	DO43907	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.25
p.D798G	DO47869	STAD	ICGC	VLSTS	DEG_SPOP_SBC_1	0.75
p.S785A	SIDM00845	Burkitt's Lymphoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.S785A	SIDM00461	Acute Myeloid Leukemia	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1111
p.V806A	22RV1	prostate	COSMIC	VLSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons