DegronMD

Uniprot ID: Q8TEJ3

Source protein: E3 ubiquitin-protein ligase SH3RF3

Source gene: SH3RF3

Class: DEG_SPOP_SBC_1

Location: 696:700

E3 ligase: SPOP

DEGRON score: 0.9715

ASA_SCORE: 80.3

COIL: 0.8804

CONS_SCORE: 0.339

DSS_SCORE: 0.5441

HELIX: 0.0336

FCONS_SCORE: 1.065

RIG_SCORE: 0.6621

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C707Y	TCGA-29-1702	OV	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1389
p.C707Y	DO29528	OV	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1389
p.N704T	TCGA-2H-A9GO	ESCA	TCGA	VLSTS	DEG_SPOP_SBC_1	0.2222
p.D710E	TCGA-AD-6895	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	0.0556
p.D710E	DO8938	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	0.0556
p.A689P	TCGA-CA-6717	COAD	TCGA	VLSTS	DEG_SPOP_SBC_1	0.1389
p.A689P	DO8264	COAD	ICGC	VLSTS	DEG_SPOP_SBC_1	0.1389
p.N704S	TCGA-EO-A3B0	UCEC	TCGA	VLSTS	DEG_SPOP_SBC_1	0.2222
p.N704S	DO219773	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	0.2222
p.L697P	DO225106	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.6471
p.S698A	DO225106	BRCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7588
p.I694V	DO233168	GACA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.2778
p.G695C	DO229015	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.S701I	DO229024	LICA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.3056
p.S698F	DO228011	SKCA	ICGC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM00985	Burkitt's Lymphoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM01109	Other Sarcomas	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM01248	Thyroid Gland Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM00190	Melanoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM00091	Ovarian Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM00710	Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM00943	Pancreatic Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM01715	Non-Cancerous	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM01323	Oral Cavity Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM01765	Osteosarcoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.S700F	SIDM01167	Thyroid Gland Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.7982
p.G706V	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1667
p.G706V	SIDM00793	Burkitt's Lymphoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1667
p.T705M	SIDM01322	Oral Cavity Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	0.1944
p.P693S	ACH-001853	Bile Duct Cancer	CCLE	VLSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1481:1485	VLSTS	SPOP	0.7831	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	334:338	VLSTS	SPOP	0.5966	More...
Q32MK0	Myosin light chain kinase 3	DEG_SPOP_SBC_1	174:178	VLSTS	SPOP	0.9947	More...
Q6IPM2	IQ domain-containing protein E	DEG_SPOP_SBC_1	318:322	VLSTS	SPOP	0.5759	More...
Q6ZMZ0	E3 ubiquitin-protein ligase RNF19B	DEG_SPOP_SBC_1	492:496	VLSTS	SPOP	0.944	More...
Q7KZI7	Serine/threonine-protein kinase MARK2	DEG_SPOP_SBC_1	475:479	VLSTS	SPOP	0.9918	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	793:797	VLSTS	SPOP	0.9931	More...
Q8TEJ3	E3 ubiquitin-protein ligase SH3RF3	DEG_SPOP_SBC_1	696:700	VLSTS	SPOP	0.9715	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	526:530	VLSTS	SPOP	0.9999	More...
Q96LA8	Protein arginine N-methyltransferase 6	DEG_SPOP_SBC_1	306:310	VLSTS	SPOP	0.5624	More...
Q9H0E7	Ubiquitin carboxyl-terminal hydrolase 44	DEG_SPOP_SBC_1	245:249	VLSTS	SPOP	0.9886	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	578:582	VLSTS	SPOP	0.9967	More...
Q9UNZ2	NSFL1 cofactor p47	DEG_SPOP_SBC_1	267:271	VLSTS	SPOP	0.7502	More...
Q5T8P6	RNA-binding protein 26	DEG_SPOP_SBC_1	687:691	VLSTS	SPOP	0.5563	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLSTS

Degron related mutations and impact score

Drug responses associated with SH3RF3 mutations

All proteins holding degron of VLSTS