DegronMD - P16144(ITGB4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1104N	TCGA-06-0213	GBM	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.D1104N	TCGA-EB-A3Y6	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.D1104N	TCGA-EB-A431	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.D1104N	DO11836	GBM	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.D1104N	DO37671	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.D1104N	DO38081	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.S1221R	TCGA-43-6143	LUSC	TCGA	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.0833
p.S1221R	DO26428	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.0833
p.R1225C	TCGA-85-8664	LUSC	TCGA	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1944
p.R1225C	DO45469	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.1944
p.A1090V	TCGA-D9-A148	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.A1090V	DO37971	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.G1089W	TCGA-EE-A184	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1667
p.G1089W	DO47442	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1667
p.P1105S	TCGA-EE-A2MM	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1667
p.P1105S	DO222678	MELA	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1667
p.P1105S	DO37770	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1667
p.I1102M	TCGA-EY-A1GS	UCEC	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.25
p.I1102M	DO43162	UCEC	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.25
p.Q1094H	TCGA-IB-7651	PAAD	TCGA	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.3056
p.Q1094H	DO46657	PAAD	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.3056
p.V1481M	TCGA-OR-A5J5	ACC	TCGA	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.7208
p.G1493R	DO48367	BLCA	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1111
p.P1495L	DO44338	CESC	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.0556
p.I1100T	DO228123	EOPC	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.3056
p.V1231I	DO233888	GACA	ICGC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.5965
p.V1231I	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.5965
p.V1231I	ACH-000669	Lung Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.5965
p.V1231I	SW900	lung	COSMIC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.5965
p.A1090S	DO229028	LICA	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation rewiring degron network	0.1944
p.P1485Q	DO37452	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.7035
p.R1483S	DO37439	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.7427
p.S1482F	DO47309	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.7982
p.R1486L	DO47303	SKCM	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.75
p.H1096Q	DO229211	THCA	ICGC	PHSTT	DEG_SPOP_SBC_1	1095:1099	Mutation altering degron motif	0.647
p.A1474T	DO42977	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.5833
p.D1487N	DO42608	UCEC	ICGC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.7222
p.N1229D	SIDM00615	Hepatocellular Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.3056
p.N1229D	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.3056
p.N1229D	SIDM01573	Plasma Cell Myeloma	GDSC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.3056
p.N1229D	JHH-6	liver	COSMIC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.3056
p.N1229D	MEG-01	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.3056
p.T1234M	SIDM00217	Colorectal Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.7423
p.T1234M	ACH-000999	Colon/Colorectal Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.7423
p.T1234M	SNU-1040	large intestine	COSMIC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation altering degron motif	0.7423
p.S1221N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.0833
p.S1221N	ACH-002222	Leukemia	CCLE	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.0833
p.S1221N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	VVSST	DEG_SPOP_SBC_1	1230:1234	Mutation rewiring degron network	0.0833
p.R1473W	SIDM00783	Colorectal Carcinoma	GDSC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1111
p.R1473W	HCT-116	large intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1111
p.L1473P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1111
p.C1483R	COLO-684	endometrium	COSMIC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.8301
p.Y1494H	GP5d	large intestine	COSMIC	VLSTS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for ITGB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGB4

UniProt ID: P16144

Entrez ID: 3691

Protein name: Integrin beta-4 (GP150) (CD antigen CD104)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGB4 in