DegronMD

Uniprot ID: P16144

Source protein: Integrin beta-4

Source gene: ITGB4

Class: DEG_SPOP_SBC_1

Location: 1095:1099

E3 ligase: SPOP

DEGRON score: 0.6709

ASA_SCORE: 31.56

COIL: 0.2818

CONS_SCORE: 0.4603

DSS_SCORE: 0.5643

HELIX: 0.0076

FCONS_SCORE: 0.898

RIG_SCORE: 0.7095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1104N	TCGA-06-0213	GBM	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1944
p.D1104N	TCGA-EB-A3Y6	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1944
p.D1104N	TCGA-EB-A431	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1944
p.D1104N	DO11836	GBM	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1944
p.D1104N	DO37671	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1944
p.D1104N	DO38081	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1944
p.A1090V	TCGA-D9-A148	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1944
p.A1090V	DO37971	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1944
p.G1089W	TCGA-EE-A184	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1667
p.G1089W	DO47442	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1667
p.P1105S	TCGA-EE-A2MM	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1667
p.P1105S	DO222678	MELA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1667
p.P1105S	DO37770	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1667
p.I1102M	TCGA-EY-A1GS	UCEC	TCGA	PHSTT	DEG_SPOP_SBC_1	0.25
p.I1102M	DO43162	UCEC	ICGC	PHSTT	DEG_SPOP_SBC_1	0.25
p.Q1094H	TCGA-IB-7651	PAAD	TCGA	PHSTT	DEG_SPOP_SBC_1	0.3056
p.Q1094H	DO46657	PAAD	ICGC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.I1100T	DO228123	EOPC	ICGC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.A1090S	DO229028	LICA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1944
p.H1096Q	DO229211	THCA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1095:1099	PHSTT	SPOP	0.6709	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	1471:1475	PHSTT	SPOP	0.961	More...
Q8NFZ4	Neuroligin-2	DEG_SPOP_SBC_1	829:833	PHSTT	SPOP	0.9949	More...
Q5SQH8	Uncharacterized protein C6orf136	DEG_SPOP_SBC_1	39:43	PHSTT	SPOP	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons