DegronMD - Q8NFZ4(NLGN2)

GO - Biological processes (BP): brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cell-cell junction maintenance [GO:0045217]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; inhibitory synapse assembly [GO:1904862]; insulin metabolic process [GO:1901142]; jump response [GO:0007630]; locomotory exploration behavior [GO:0035641]; modulation of chemical synaptic transmission [GO:0050804]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter-gated ion channel clustering [GO:0072578]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; positive regulation of t-SNARE clustering [GO:1904034]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynapse assembly [GO:0099054]; presynaptic membrane assembly [GO:0097105]; protein localization to cell surface [GO:0034394]; protein localization to synapse [GO:0035418]; regulation of AMPA receptor activity [GO:2000311]; regulation of presynapse assembly [GO:1905606]; regulation of respiratory gaseous exchange by nervous system process [GO:0002087]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic transmission, GABAergic [GO:0051932]; synaptic vesicle endocytosis [GO:0048488]; terminal button organization [GO:0072553]; thigmotaxis [GO:0001966] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P767L	TCGA-FW-A3R5	SKCM	TCGA	PPDY	ITCH	766:769	Mutation altering degron motif	0.7582
p.P767L	DO37406	SKCM	ICGC	PPDY	ITCH	766:769	Mutation altering degron motif	0.7582
p.R775Q	DO233207	GACA	ICGC	PPDY	ITCH	766:769	Mutation rewiring degron network	0.1667
p.R774S	DO233947	GACA	ICGC	PPDY	ITCH	766:769	Mutation rewiring degron network	0.1944
p.A758D	DO229058	LICA	ICGC	PPDY	ITCH	766:769	Mutation rewiring degron network	0.1111
p.R834L	DO229009	LICA	ICGC	PHSTT	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.3056
p.P757L	DO50694	ORCA	ICGC	PPDY	ITCH	766:769	Mutation rewiring degron network	0.0833
p.H828P	DO229208	THCA	ICGC	PHSTT	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.3056
p.H828P	DO229218	THCA	ICGC	PHSTT	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.3056
p.P757S	DO229245	THCA	ICGC	PPDY	ITCH	766:769	Mutation rewiring degron network	0.0833
p.R762H	SIDM01962	Colorectal Carcinoma	GDSC	PPDY	ITCH	766:769	Mutation rewiring degron network	0.2222
p.P829A	SIDM00084	Glioblastoma	GDSC	PHSTT	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.6392
p.P829A	ACH-000376	Brain Cancer	CCLE	PHSTT	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.6392
p.D778G	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPDY	ITCH	766:769	Mutation rewiring degron network	0.0833
p.H828Y	ACH-001642	Lymphoma	CCLE	PHSTT	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NLGN2

UniProt ID: Q8NFZ4

Entrez ID: 57555

Protein name: Neuroligin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NLGN2 in