DegronMD

Uniprot ID: Q8NFZ4

Source protein: Neuroligin-2

Source gene: NLGN2

Class: DEG_SPOP_SBC_1

Location: 829:833

E3 ligase: SPOP

DEGRON score: 0.9949

ASA_SCORE: 80.04

COIL: 0.7844

CONS_SCORE: 0.2725

DSS_SCORE: 0.9366

HELIX: 0.0494

FCONS_SCORE: 1.182

RIG_SCORE: 0.6518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R834L	DO229009	LICA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.H828P	DO229208	THCA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.H828P	DO229218	THCA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.P829A	SIDM00084	Glioblastoma	GDSC	PHSTT	DEG_SPOP_SBC_1	0.6392
p.P829A	ACH-000376	Brain Cancer	CCLE	PHSTT	DEG_SPOP_SBC_1	0.6392
p.H828Y	ACH-001642	Lymphoma	CCLE	PHSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1095:1099	PHSTT	SPOP	0.6709	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	1471:1475	PHSTT	SPOP	0.961	More...
Q8NFZ4	Neuroligin-2	DEG_SPOP_SBC_1	829:833	PHSTT	SPOP	0.9949	More...
Q5SQH8	Uncharacterized protein C6orf136	DEG_SPOP_SBC_1	39:43	PHSTT	SPOP	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons