DegronMD

Uniprot ID: Q5SQH8

Source protein: Uncharacterized protein C6orf136

Source gene: C6orf136

Class: DEG_SPOP_SBC_1

Location: 39:43

E3 ligase: SPOP

DEGRON score: 0.9871

ASA_SCORE: 77.18

COIL: 0.9304

CONS_SCORE: 0.2921

DSS_SCORE: 0.5014

HELIX: 0.0204

FCONS_SCORE: 0.9276

RIG_SCORE: 0.6474

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R33G	TCGA-A4-7584	KIRP	TCGA	PHSTT	DEG_SPOP_SBC_1	0.1667
p.R33G	DO20869	KIRP	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1667
p.E38K	TCGA-BF-AAOX	SKCM	TCGA	PHSTT	DEG_SPOP_SBC_1	0.3056
p.E38K	DO223907	SKCM	ICGC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.E30Q	TCGA-L5-A43H	ESCA	TCGA	PHSTT	DEG_SPOP_SBC_1	0.0833
p.E38D	DO225114	BRCA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.3056
p.R46C	DO233941	GACA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.25
p.A51E	DO44792	LICA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1111
p.R33S	DO230529	LUSC	ICGC	PHSTT	DEG_SPOP_SBC_1	0.1667
p.L52R	DO229453	SKCA	ICGC	PHSTT	DEG_SPOP_SBC_1	0.0833
p.R46H	SIDM01076	B-Lymphoblastic Leukemia	GDSC	PHSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16144	Integrin beta-4	DEG_SPOP_SBC_1	1095:1099	PHSTT	SPOP	0.6709	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	1471:1475	PHSTT	SPOP	0.961	More...
Q8NFZ4	Neuroligin-2	DEG_SPOP_SBC_1	829:833	PHSTT	SPOP	0.9949	More...
Q5SQH8	Uncharacterized protein C6orf136	DEG_SPOP_SBC_1	39:43	PHSTT	SPOP	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons