DegronMD - Q68CP9(ARID2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R247H	TCGA-25-1319	OV	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1667
p.V1493I	TCGA-29-1693	OV	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation altering degron motif	0.5965
p.V1493I	TCGA-98-8021	LUSC	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation altering degron motif	0.5965
p.R1464H	TCGA-34-2596	LUSC	TCGA	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1464H	TCGA-VQ-A91D	STAD	TCGA	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.Q997H	TCGA-44-8120	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.1667
p.P851S	TCGA-55-8511	LUAD	TCGA	PPQY	ITCH	850:853	Mutation altering degron motif	0.6752
p.S251Y	TCGA-66-2789	LUSC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.0556
p.S251Y	DO27279	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.0556
p.R623L	TCGA-70-6722	LUSC	TCGA	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.S626F	TCGA-90-A4EE	LUSC	TCGA	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.6111
p.T812N	TCGA-A5-A0G2	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.7055
p.D232Y	TCGA-A5-A1OF	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.3056
p.D232Y	DO42568	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.3056
p.S990L	TCGA-AP-A056	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation altering degron motif	0.7667
p.S990L	TCGA-ER-A19E	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation altering degron motif	0.7667
p.D1488N	TCGA-AP-A1DV	UCEC	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation altering degron motif	0.6932
p.D1488N	TCGA-DU-6392	LGG	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation altering degron motif	0.6932
p.H800Y	TCGA-AX-A2HD	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0556
p.R247S	TCGA-B5-A0JY	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1667
p.F236L	TCGA-B5-A1MR	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.587
p.F236L	DO41758	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.587
p.S1470L	TCGA-B5-A1MW	UCEC	TCGA	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation blocking phosphorylation signal	0.75
p.G803D	TCGA-BF-AAP7	SKCM	TCGA	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1389
p.P1590Q	TCGA-BQ-7053	KIRP	TCGA	PPTY	ITCH	1581:1584	Mutation rewiring degron network	0.1667
p.P1590Q	TCGA-CR-7385	HNSC	TCGA	PPTY	ITCH	1581:1584	Mutation rewiring degron network	0.1667
p.R1464C	TCGA-BR-4292	STAD	TCGA	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1464C	SIDM00253	Neuroblastoma	GDSC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1464C	NB6	autonomic ganglia	COSMIC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.D239V	TCGA-BR-4370	STAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.6674
p.D239V	DO38499	STAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.6674
p.R623C	TCGA-BS-A0UF	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.R623C	TCGA-E6-A1LX	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.V241I	TCGA-CD-A4MG	STAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.5965
p.V241I	DO48009	STAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.5965
p.G818C	TCGA-D3-A2JP	SKCM	TCGA	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2222
p.P978Q	TCGA-D3-A2JP	SKCM	TCGA	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.1944
p.P978Q	TCGA-D3-A2JP	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.0833
p.S992Y	TCGA-D3-A8GL	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.3056
p.S1501F	TCGA-DD-AACD	LIHC	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.1389
p.Y611C	TCGA-DI-A1BU	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.T856I	TCGA-EB-A41A	SKCM	TCGA	PPQY	ITCH	850:853	Mutation rewiring degron network	0.25
p.Q817H	TCGA-EE-A17Z	SKCM	TCGA	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.25
p.R247C	TCGA-EO-A22R	UCEC	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1667
p.R247C	TCGA-R5-A7ZI	STAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1667
p.S1496F	TCGA-FW-A3R5	SKCM	TCGA	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation blocking phosphorylation signal	0.7222
p.T993S	TCGA-GL-A59R	KIRP	TCGA	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.2778
p.S813F	TCGA-HB-A3YV	SARC	TCGA	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.7982
p.S1466I	TCGA-HG-A9SC	CESC	TCGA	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1944
p.T1593A	TCGA-IB-7651	PAAD	TCGA	PPTY	ITCH	1581:1584	Mutation rewiring degron network	0.0833
p.D629H	TCGA-K4-A3WS	BLCA	TCGA	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.0833
p.T229S	TCGA-SS-A7HO	COAD	TCGA	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.2222
p.T229S	DO223705	COAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.2222
p.T816M	DO492	BLCA	ICGC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.T816M	DO41638	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.D239H	DO480	BLCA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.6577
p.P808A	DO465	BLCA	ICGC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.P808A	DO27128	LUSC	ICGC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.V613L	DO234241	ESAD	ICGC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.P966L	DO233731	GACA	ICGC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation altering degron motif	0.6471
p.D958V	DO12076	GBM	ICGC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.1111
p.N969S	DO52095	HNSC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation altering degron motif	0.7069
p.S614C	DO20841	KIRP	ICGC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2778
p.H627Y	DO22237	LGG	ICGC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1389
p.A860T	DO22237	LGG	ICGC	PPQY	ITCH	850:853	Mutation rewiring degron network	0.1389
p.R233L	DO229027	LICA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.8428
p.R233L	DO27755	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.8428
p.V227F	DO229032	LICA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1667
p.G608R	DO50970	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1111
p.D958H	DO231747	LINC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.1111
p.W250L	DO23742	LUAD	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.0833
p.Q607H	DO45402	LUAD	ICGC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.0833
p.Q625P	DO26467	LUSC	ICGC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.V820A	DO26444	LUSC	ICGC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1667
p.M616I	DO50095	LUSC	ICGC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7618
p.A243S	DO45527	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.2778
p.S236F	DO45513	LUSC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.7982
p.S236F	DO222494	MELA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.7982
p.R233C	DO222644	MELA	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.8301
p.R233C	DO41020	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.8301
p.R233C	DO41488	UCEC	ICGC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.8301
p.G815A	DO32805	PAAD	ICGC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.H994Y	DO37583	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.25
p.S961R	DO40879	UCEC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.1944
p.G979C	DO223286	UCEC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.1667
p.G979C	DO223286	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.1111
p.S961I	DO43041	UCEC	ICGC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.1944
p.C840W	DO41542	UCEC	ICGC	PPQY	ITCH	850:853	Mutation rewiring degron network	0.0556
p.K851T	DO41211	UCEC	ICGC	PPQY	ITCH	850:853	Mutation altering degron motif	0.7306
p.D239N	SIDM00216	Colorectal Carcinoma	GDSC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.5821
p.D239N	ACH-000989	Colon/Colorectal Cancer	CCLE	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation altering degron motif	0.5821
p.A810P	SIDM00450	Acute Myeloid Leukemia	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.6392
p.A810P	SIDM01034	B-Lymphoblastic Leukemia	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.6392
p.A810P	SIDM00367	Small Cell Lung Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.6392
p.A810P	SIDM00243	Other Solid Cancers	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.6392
p.A810P	SIDM01658	Unknown	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.6392
p.A810P	SIDM01694	B-Lymphoblastic Leukemia	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.6392
p.T1475A	SIDM00845	Burkitt's Lymphoma	GDSC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7139
p.S1476P	SIDM00845	Burkitt's Lymphoma	GDSC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.3056
p.A1498T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.2222
p.A1498T	SIDM00954	Breast Carcinoma	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.2222
p.A1498T	SIDM01173	Rhabdomyosarcoma	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.2222
p.P1461L	SIDM01175	Other Sarcomas	GDSC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.0556
p.P1461L	ACH-002309	Sarcoma	CCLE	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.0556
p.P1461L	SW684	soft tissue	COSMIC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.0556
p.I808T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.I808T	H513	pleura	COSMIC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.D248G	SIDM00710	Small Cell Lung Carcinoma	GDSC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1389
p.D248G	ACH-000394	Lung Cancer	CCLE	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1389
p.D248G	NCI-H2081	lung	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.1389
p.R1464P	SIDM00245	Small Cell Lung Carcinoma	GDSC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.R1464P	MS-1	lung	COSMIC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation rewiring degron network	0.1389
p.D230Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.25
p.D230Y	ACH-000951	Lung Cancer	CCLE	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.25
p.D230Y	NCI-H2342	lung	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.25
p.F802L	SIDM00534	Colorectal Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1111
p.F802L	ACH-000986	Colon/Colorectal Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1111
p.F802L	HT-115	large intestine	COSMIC	ACTST	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.1111
p.T1474A	SIDM01619	Endometrial Carcinoma	GDSC	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7139
p.T1474A	ACH-000984	Endometrial/Uterine Cancer	CCLE	PHSTT	DEG_SPOP_SBC_1	1471:1475	Mutation altering degron motif	0.7139
p.Q1591H	SIDM01619	Endometrial Carcinoma	GDSC	PPTY	ITCH	1581:1584	Mutation rewiring degron network	0.1389
p.R1504W	SIDM01525	Acute Myeloid Leukemia	GDSC	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.0556
p.V1503I	ACH-000185	Non-Cancerous	CCLE	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.0833
p.G957D	ACH-001063	Ovarian Cancer	CCLE	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.0833
p.P970L	ACH-001550	Skin Cancer	CCLE	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation altering degron motif	0.7582
p.S1491L	ACH-001982	Metastasis	CCLE	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation altering degron motif	0.6556
p.S989L	ACH-001991	Primary	CCLE	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation altering degron motif	0.7667
p.S988A	Daudi	haematopoietic and lymphoid tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation altering degron motif	0.7588
p.S988A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation altering degron motif	0.7588
p.Y1502H	CCK-81	large intestine	COSMIC	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.1111
p.W244R	HCC1569	breast	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.25
p.S859Y	Mewo	skin	COSMIC	PPQY	ITCH	850:853	Mutation rewiring degron network	0.1667
p.S618A	SNU-1040	large intestine	COSMIC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7588
p.S610F	HT-115	large intestine	COSMIC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1667
p.P982Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.0833
p.P982Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.1944
p.P982Q	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PNITPSSS	DEG_SCF_FBW7_1	966:973	Mutation rewiring degron network	0.0833
p.P982Q	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.1944
p.W1487R	HCC1569	breast	COSMIC	DSGSKVS	DEG_SCF_TRCP1_1	1488:1494	Mutation rewiring degron network	0.3056
p.I986S	EN	endometrium	COSMIC	AMSSS	DEG_SPOP_SBC_1	987:991	Mutation rewiring degron network	0.3056
p.T628I	RL95-2	endometrium	COSMIC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1111
p.P244A	CHP-134	autonomic ganglia	COSMIC	FVKFWKDIV	DEG_MDM2_SWIB_1	233:241	Mutation rewiring degron network	0.25
p.H616N	TGBC11TKB	stomach	COSMIC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7423
p.S618Y	Mewo	skin	COSMIC	PVSTS	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID2

UniProt ID: Q68CP9

Entrez ID: 196528

Protein name: AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARID2 in