DegronMD

Uniprot ID: Q68CP9

Source protein: AT-rich interactive domain-containing protein 2

Source gene: ARID2

Class: DEG_SPOP_SBC_1

Location: 810:814

E3 ligase: SPOP

DEGRON score: 0.9874

ASA_SCORE: 83.78

COIL: 0.9292

CONS_SCORE: 0.2985

DSS_SCORE: 0.4034

HELIX: 0.0204

FCONS_SCORE: 0.9614

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T812N	TCGA-A5-A0G2	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	0.7055
p.H800Y	TCGA-AX-A2HD	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	0.0556
p.G803D	TCGA-BF-AAP7	SKCM	TCGA	ACTST	DEG_SPOP_SBC_1	0.1389
p.G818C	TCGA-D3-A2JP	SKCM	TCGA	ACTST	DEG_SPOP_SBC_1	0.2222
p.Q817H	TCGA-EE-A17Z	SKCM	TCGA	ACTST	DEG_SPOP_SBC_1	0.25
p.S813F	TCGA-HB-A3YV	SARC	TCGA	ACTST	DEG_SPOP_SBC_1	0.7982
p.T816M	DO492	BLCA	ICGC	ACTST	DEG_SPOP_SBC_1	0.2778
p.T816M	DO41638	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	0.2778
p.P808A	DO465	BLCA	ICGC	ACTST	DEG_SPOP_SBC_1	0.2778
p.P808A	DO27128	LUSC	ICGC	ACTST	DEG_SPOP_SBC_1	0.2778
p.V820A	DO26444	LUSC	ICGC	ACTST	DEG_SPOP_SBC_1	0.1667
p.G815A	DO32805	PAAD	ICGC	ACTST	DEG_SPOP_SBC_1	0.3056
p.A810P	SIDM00450	Acute Myeloid Leukemia	GDSC	ACTST	DEG_SPOP_SBC_1	0.6392
p.A810P	SIDM01034	B-Lymphoblastic Leukemia	GDSC	ACTST	DEG_SPOP_SBC_1	0.6392
p.A810P	SIDM00367	Small Cell Lung Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	0.6392
p.A810P	SIDM00243	Other Solid Cancers	GDSC	ACTST	DEG_SPOP_SBC_1	0.6392
p.A810P	SIDM01658	Unknown	GDSC	ACTST	DEG_SPOP_SBC_1	0.6392
p.A810P	SIDM01694	B-Lymphoblastic Leukemia	GDSC	ACTST	DEG_SPOP_SBC_1	0.6392
p.I808T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	0.2778
p.I808T	H513	pleura	COSMIC	ACTST	DEG_SPOP_SBC_1	0.2778
p.F802L	SIDM00534	Colorectal Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	0.1111
p.F802L	ACH-000986	Colon/Colorectal Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	0.1111
p.F802L	HT-115	large_intestine	COSMIC	ACTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14534	Squalene monooxygenase	DEG_SPOP_SBC_1	114:118	ACTST	SPOP	0.963	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	810:814	ACTST	SPOP	0.9874	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	1658:1662	ACTST	SPOP	0.8141	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	223:227	ACTST	SPOP	0.6126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons