DegronMD

Uniprot ID: Q14534

Source protein: Squalene monooxygenase

Source gene: SQLE

Class: DEG_SPOP_SBC_1

Location: 114:118

E3 ligase: SPOP

DEGRON score: 0.963

ASA_SCORE: 81.88

COIL: 0.8954

CONS_SCORE: 0.3809

DSS_SCORE: 0.4706

HELIX: 0.0732

FCONS_SCORE: 0.819

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V126L	TCGA-ZF-AA58	BLCA	TCGA	ACTST	DEG_SPOP_SBC_1	0.1111
p.V126L	DO219100	BLCA	ICGC	ACTST	DEG_SPOP_SBC_1	0.1111
p.Q124H	DO229034	LICA	ICGC	ACTST	DEG_SPOP_SBC_1	0.1667
p.P124L	DO27915	ORCA	ICGC	ACTST	DEG_SPOP_SBC_1	0.1667
p.P114S	DO37422	SKCM	ICGC	ACTST	DEG_SPOP_SBC_1	0.6752
p.T112I	SIDM01118	Small Cell Lung Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	0.2778
p.T112I	ACH-002175	Lung Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	0.2778
p.T112I	NCI-H740	lung	COSMIC	ACTST	DEG_SPOP_SBC_1	0.2778
p.L109V	ACH-002680	Brain Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14534	Squalene monooxygenase	DEG_SPOP_SBC_1	114:118	ACTST	SPOP	0.963	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	810:814	ACTST	SPOP	0.9874	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	1658:1662	ACTST	SPOP	0.8141	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	223:227	ACTST	SPOP	0.6126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons