DegronMD

Uniprot ID: Q9H2D6

Source protein: TRIO and F-actin-binding protein

Source gene: TRIOBP

Class: DEG_SPOP_SBC_1

Location: 1658:1662

E3 ligase: SPOP

DEGRON score: 0.8141

ASA_SCORE: 83.54

COIL: 0.927

CONS_SCORE: 0.6106

DSS_SCORE: 0.5178

HELIX: 0.04

FCONS_SCORE: 0.9644

RIG_SCORE: 0.6888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1649H	TCGA-33-A5GW	LUSC	TCGA	ACTST	DEG_SPOP_SBC_1	0.0833
p.Q1649H	DO219122	LUSC	ICGC	ACTST	DEG_SPOP_SBC_1	0.0833
p.S1648P	TCGA-B5-A1MR	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	0.0556
p.S1648P	DO41758	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	0.0556
p.V1652F	TCGA-CK-4951	COAD	TCGA	ACTST	DEG_SPOP_SBC_1	0.1667
p.V1652F	DO10582	COAD	ICGC	ACTST	DEG_SPOP_SBC_1	0.1667
p.T1660S	TCGA-DQ-5625	HNSC	TCGA	ACTST	DEG_SPOP_SBC_1	0.6005
p.T1660S	DO15414	HNSC	ICGC	ACTST	DEG_SPOP_SBC_1	0.6005
p.K1666N	TCGA-E6-A1LX	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	0.3333
p.K1666N	DO41020	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	0.3333
p.P1657T	DO230343	COCA	ICGC	ACTST	DEG_SPOP_SBC_1	0.3056
p.S1650I	DO229038	LICA	ICGC	ACTST	DEG_SPOP_SBC_1	0.1111
p.L1654Q	DO50785	LIRI	ICGC	ACTST	DEG_SPOP_SBC_1	0.2222
p.C1659R	DO49460	PACA	ICGC	ACTST	DEG_SPOP_SBC_1	0.719
p.I1667S	SIDM00965	Small Cell Lung Carcinoma	GDSC	ACTST	DEG_SPOP_SBC_1	0.1944
p.I1667S	ACH-000800	Lung Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	0.1944
p.I1667S	NCI-H446	lung	COSMIC	ACTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14534	Squalene monooxygenase	DEG_SPOP_SBC_1	114:118	ACTST	SPOP	0.963	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	810:814	ACTST	SPOP	0.9874	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	1658:1662	ACTST	SPOP	0.8141	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	223:227	ACTST	SPOP	0.6126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons