DegronMD - Q5HYC2(KIAA2026)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R234Q	TCGA-06-5858	GBM	TCGA	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1389
p.R234Q	DO10892	GBM	ICGC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1389
p.S1828Y	TCGA-AA-3984	COAD	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.1389
p.S1828Y	TCGA-AJ-A3EL	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.1389
p.N1760S	TCGA-AA-3984	COAD	TCGA	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation rewiring degron network	0.1667
p.N1760S	TCGA-AA-3984	COAD	TCGA	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1944
p.R230Q	TCGA-AP-A1DK	UCEC	TCGA	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.25
p.R230Q	DO42033	UCEC	ICGC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.25
p.S1843F	TCGA-AX-A2HC	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.3056
p.A1503T	TCGA-B5-A11J	UCEC	TCGA	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.1667
p.F1826V	TCGA-B5-A1MR	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.0833
p.A1495V	TCGA-B5-A1MR	UCEC	TCGA	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation altering degron motif	0.5825
p.T1328I	TCGA-B6-A0WY	BRCA	TCGA	PKSTT	DEG_SPOP_SBC_1	1324:1328	Mutation altering degron motif	0.7078
p.Q1300L	TCGA-BG-A222	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.1667
p.S1765L	TCGA-CA-6718	COAD	TCGA	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.0556
p.S1765L	SIDM01588	Endometrial Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.0556
p.S1765L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.0556
p.C2024Y	TCGA-D1-A160	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.1389
p.S1828F	TCGA-D1-A17Q	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.1389
p.G221V	TCGA-D8-A1X5	BRCA	TCGA	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2778
p.G221V	DO3590	BRCA	ICGC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2778
p.A1752V	TCGA-FI-A2D5	UCEC	TCGA	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation altering degron motif	0.5825
p.A1752V	TCGA-FI-A2D5	UCEC	TCGA	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation altering degron motif	0.5825
p.N1630H	TCGA-FU-A3HZ	CESC	TCGA	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.0833
p.S2021A	TCGA-QF-A5YS	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.0556
p.T1342A	TCGA-UY-A8OB	BLCA	TCGA	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.3056
p.T1312A	DO219037	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.2778
p.L1501I	DO225334	BRCA	ICGC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.L2025F	DO2401	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.1667
p.T1298I	DO3424	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.1111
p.K1845R	DO223732	CESC	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.25
p.T1487A	DO10020	COAD	ICGC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.25
p.S1835I	DO52458	COCA	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation altering degron motif	0.7341
p.I2024V	DO234350	ESAD	ICGC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.1389
p.S1326F	DO228771	GACA	ICGC	PKSTT	DEG_SPOP_SBC_1	1324:1328	Mutation altering degron motif	0.7982
p.R1743H	DO233898	GACA	ICGC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation rewiring degron network	0.1944
p.R1743H	DO233898	GACA	ICGC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1111
p.R1743H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation rewiring degron network	0.1944
p.R1743H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1111
p.G1627E	DO10880	GBM	ICGC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1667
p.R1753W	DO230659	LAML	ICGC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation altering degron motif	0.8634
p.R1753W	DO230659	LAML	ICGC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation altering degron motif	0.8634
p.R1753W	DO231140	LAML	ICGC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation altering degron motif	0.8634
p.R1753W	DO231140	LAML	ICGC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation altering degron motif	0.8634
p.S1827Y	DO229015	LICA	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.1111
p.A1825E	DO229028	LICA	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.0556
p.P233Q	DO229026	LICA	ICGC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1667
p.A2023D	DO229034	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.1111
p.A2032E	DO229006	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation altering degron motif	0.7701
p.T232K	DO229008	LICA	ICGC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1944
p.H1345Y	DO52202	LIHC	ICGC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.2222
p.A1617T	DO24729	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.7139
p.R1753L	DO25000	LUAD	ICGC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation altering degron motif	0.8428
p.R1753L	DO25000	LUAD	ICGC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation altering degron motif	0.8428
p.I1846T	DO26444	LUSC	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.2222
p.N1629Y	DO26455	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.1111
p.P1484S	DO222843	MELA	ICGC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.1667
p.R229C	DO228138	PBCA	ICGC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2778
p.R229C	ACH-000143	Lung Cancer	CCLE	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2778
p.A1494T	DO232224	PBCA	ICGC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation altering degron motif	0.7139
p.T2030S	DO220172	SARC	ICGC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.3056
p.P1490T	DO37738	SKCM	ICGC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation altering degron motif	0.7031
p.I1763M	DO47769	STAD	ICGC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation rewiring degron network	0.0833
p.I1763M	DO47769	STAD	ICGC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1111
p.D1351N	DO42033	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.0556
p.T1347I	DO41584	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.1667
p.S1615Y	DO41799	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation rewiring degron network	0.2778
p.K1845N	DO41235	UCEC	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.25
p.Q1757H	DO42793	UCEC	ICGC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation substituting flanking lysine	0.3611
p.A2023T	DO41331	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.1111
p.A1844S	SIDM02022	Colorectal Carcinoma	GDSC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.2778
p.N1486S	SIDM01020	Plasma Cell Myeloma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00535	Chondrosarcoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00362	Burkitt's Lymphoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00465	Ovarian Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00457	Plasma Cell Myeloma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00260	Gastric Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00612	Glioma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00549	B-Lymphoblastic Leukemia	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00616	Hepatocellular Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00591	Oral Cavity Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM01551	Gastric Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM01660	Kidney Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM01472	Hepatocellular Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM00248	Gastric Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM01575	Plasma Cell Myeloma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM01413	Oral Cavity Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.N1486S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.2222
p.A237P	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.0556
p.A237P	ACH-002272	Lymphoma	CCLE	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.0556
p.A237P	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.0556
p.D218E	SIDM00845	Burkitt's Lymphoma	GDSC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1944
p.D218E	ACH-000786	Lymphoma	CCLE	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1944
p.D218E	Daudi	haematopoietic and lymphoid tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1944
p.D218E	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1944
p.G1338E	SIDM00506	Small Cell Lung Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation altering degron motif	0.6087
p.G1338E	ACH-000508	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation altering degron motif	0.6087
p.G1338E	COR-L88	lung	COSMIC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation altering degron motif	0.6087
p.G1846R	SIDM00084	Glioblastoma	GDSC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.2222
p.G1846R	SF295	central nervous system	COSMIC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.2222
p.A1332V	SIDM00660	Colorectal Carcinoma	GDSC	PKSTT	DEG_SPOP_SBC_1	1324:1328	Mutation rewiring degron network	0.2222
p.A1332V	SIDM00660	Colorectal Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.1944
p.A1332V	ACH-000985	Colon/Colorectal Cancer	CCLE	PKSTT	DEG_SPOP_SBC_1	1324:1328	Mutation rewiring degron network	0.2222
p.A1332V	ACH-000985	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.1944
p.A1332V	LS-411N	large intestine	COSMIC	PKSTT	DEG_SPOP_SBC_1	1324:1328	Mutation rewiring degron network	0.2222
p.A1332V	LS-411N	large intestine	COSMIC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation rewiring degron network	0.1944
p.K1609R	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation substituting flanking lysine	0.2222
p.K1609R	ACH-002393	Lymphoma	CCLE	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation substituting flanking lysine	0.2222
p.K1609R	CRO-AP3	NS	COSMIC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation substituting flanking lysine	0.2222
p.T1620R	SIDM00685	Glioblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.7876
p.T1620R	LN-18	central nervous system	COSMIC	PLSTS	DEG_SPOP_SBC_1	1617:1621	Mutation altering degron motif	0.7876
p.T1313S	SIDM01086	B-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.25
p.T1313S	ACH-000874	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.25
p.T1313S	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.25
p.P2025S	SIDM00641	Burkitt's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation rewiring degron network	0.1667
p.P1763S	SIDM01665	Colorectal Carcinoma	GDSC	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation rewiring degron network	0.0833
p.P1763S	SIDM01665	Colorectal Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1111
p.P1763S	ACH-000089	Colon/Colorectal Cancer	CCLE	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation rewiring degron network	0.0833
p.P1763S	ACH-000089	Colon/Colorectal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1111
p.Q1319H	ACH-000071	Non-Cancerous	CCLE	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.0833
p.Q1319H	ACH-000071	Non-Cancerous	CCLE	PKSTT	DEG_SPOP_SBC_1	1324:1328	Mutation rewiring degron network	0.1944
p.T1339K	ACH-000871	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation altering degron motif	0.7306
p.T1745M	ACH-001419	Breast Cancer	CCLE	LPTPATT	DEG_SCF_FBW7_1	1748:1754	Mutation rewiring degron network	0.25
p.T1745M	ACH-001419	Breast Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1667
p.G1834R	SNU-1040	large intestine	COSMIC	LVKTPSYS	DEG_SCF_FBW7_1	1835:1842	Mutation rewiring degron network	0.3056
p.G1308E	COR-L88	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation altering degron motif	0.7199
p.S2033F	PE/CA-PJ15	upper aerodigestive tract	COSMIC	PSSTS	DEG_SPOP_SBC_1	2031:2035	Mutation altering degron motif	0.7982
p.P1482T	IGROV-1	ovary	COSMIC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.1111
p.K1340R	LNCaP-Clone-FGC	prostate	COSMIC	AGTTT	DEG_SPOP_SBC_1	1337:1341	Mutation altering degron motif	0.7237
p.P1503L	EB-3	haematopoietic and lymphoid tissue	COSMIC	INMTPALT	DEG_SCF_FBW7_1	1490:1497	Mutation rewiring degron network	0.1667
p.T225P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7031
p.T225P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ACTST	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7031
p.A1302V	LS-411N	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	1306:1310	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA2026

UniProt ID: Q5HYC2

Entrez ID: 158358

Protein name: Uncharacterized protein KIAA2026

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA2026 in