DegronMD

Uniprot ID: Q5HYC2

Source protein: Uncharacterized protein KIAA2026

Source gene: KIAA2026

Class: DEG_SCF_FBW7_1

Location: 1835:1842

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 108.5

COIL: 0.9529

CONS_SCORE: 0.2353

DSS_SCORE: 0.5219

HELIX: 0.0129

FCONS_SCORE: 0.8529

RIG_SCORE: 0.7068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1828Y	TCGA-AA-3984	COAD	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	0.1389
p.S1828Y	TCGA-AJ-A3EL	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	0.1389
p.S1843F	TCGA-AX-A2HC	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	0.3056
p.F1826V	TCGA-B5-A1MR	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	0.0833
p.S1828F	TCGA-D1-A17Q	UCEC	TCGA	LVKTPSYS	DEG_SCF_FBW7_1	0.1389
p.K1845R	DO223732	CESC	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	0.25
p.S1835I	DO52458	COCA	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	0.7341
p.S1827Y	DO229015	LICA	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	0.1111
p.A1825E	DO229028	LICA	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	0.0556
p.I1846T	DO26444	LUSC	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	0.2222
p.K1845N	DO41235	UCEC	ICGC	LVKTPSYS	DEG_SCF_FBW7_1	0.25
p.A1844S	SIDM02022	Colorectal Carcinoma	GDSC	LVKTPSYS	DEG_SCF_FBW7_1	0.2778
p.G1846R	SIDM00084	Glioblastoma	GDSC	LVKTPSYS	DEG_SCF_FBW7_1	0.2222
p.G1846R	SF295	central_nervous_system	COSMIC	LVKTPSYS	DEG_SCF_FBW7_1	0.2222
p.G1834R	SNU-1040	large_intestine	COSMIC	LVKTPSYS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SCF_FBW7_1	1835:1842	LVKTPSYS	FBXW7	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons