DegronMD

Uniprot ID: Q5HYC2

Source protein: Uncharacterized protein KIAA2026

Source gene: KIAA2026

Class: DEG_SCF_FBW7_1

Location: 1748:1754

E3 ligase: FBXW7

DEGRON score: 0.9398

ASA_SCORE: 95.3857

COIL: 0.9601

CONS_SCORE: 0.1925

DSS_SCORE: 0.2953

HELIX: 0.0093

FCONS_SCORE: 0.9256

RIG_SCORE: 0.7444

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1760S	TCGA-AA-3984	COAD	TCGA	LPTPATT	DEG_SCF_FBW7_1	0.1667
p.A1752V	TCGA-FI-A2D5	UCEC	TCGA	LPTPATT	DEG_SCF_FBW7_1	0.5825
p.R1743H	DO233898	GACA	ICGC	LPTPATT	DEG_SCF_FBW7_1	0.1944
p.R1743H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPATT	DEG_SCF_FBW7_1	0.1944
p.R1753W	DO230659	LAML	ICGC	LPTPATT	DEG_SCF_FBW7_1	0.8634
p.R1753W	DO231140	LAML	ICGC	LPTPATT	DEG_SCF_FBW7_1	0.8634
p.R1753L	DO25000	LUAD	ICGC	LPTPATT	DEG_SCF_FBW7_1	0.8428
p.I1763M	DO47769	STAD	ICGC	LPTPATT	DEG_SCF_FBW7_1	0.0833
p.Q1757H	DO42793	UCEC	ICGC	LPTPATT	DEG_SCF_FBW7_1	0.3611
p.P1763S	SIDM01665	Colorectal Carcinoma	GDSC	LPTPATT	DEG_SCF_FBW7_1	0.0833
p.P1763S	ACH-000089	Colon/Colorectal Cancer	CCLE	LPTPATT	DEG_SCF_FBW7_1	0.0833
p.T1745M	ACH-001419	Breast Cancer	CCLE	LPTPATT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SCF_FBW7_1	1748:1754	LPTPATT	FBXW7	0.9398	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons