DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PLSTS
Uniprot ID:
Q5HYC2
Source protein:
Uncharacterized protein KIAA2026
Source gene:
KIAA2026
Class:
DEG_SPOP_SBC_1
Location:
1617:1621
E3 ligase:
SPOP
DEGRON score:
0.5245
ASA_SCORE:
86.1
COIL:
0.8842
CONS_SCORE:
0.2743
DSS_SCORE:
0.3769
HELIX:
0.0192
FCONS_SCORE:
0.935
RIG_SCORE:
0.6946
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N1630H
TCGA-FU-A3HZ
CESC
TCGA
PLSTS
DEG_SPOP_SBC_1
0.0833
p.G1627E
DO10880
GBM
ICGC
PLSTS
DEG_SPOP_SBC_1
0.1667
p.A1617T
DO24729
LUAD
ICGC
PLSTS
DEG_SPOP_SBC_1
0.7139
p.N1629Y
DO26455
LUSC
ICGC
PLSTS
DEG_SPOP_SBC_1
0.1111
p.S1615Y
DO41799
UCEC
ICGC
PLSTS
DEG_SPOP_SBC_1
0.2778
p.K1609R
SIDM00070
B-Cell Non-Hodgkin's Lymphoma
GDSC
PLSTS
DEG_SPOP_SBC_1
0.2222
p.K1609R
ACH-002393
Lymphoma
CCLE
PLSTS
DEG_SPOP_SBC_1
0.2222
p.K1609R
CRO-AP3
NS
COSMIC
PLSTS
DEG_SPOP_SBC_1
0.2222
p.T1620R
SIDM00685
Glioblastoma
GDSC
PLSTS
DEG_SPOP_SBC_1
0.7876
p.T1620R
LN-18
central_nervous_system
COSMIC
PLSTS
DEG_SPOP_SBC_1
0.7876
Drug responses associated with KIAA2026 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00167
Eyes absent homolog 2
DEG_SPOP_SBC_1
196:200
PLSTS
SPOP
0.8269
More...
O95628
CCR4-NOT transcription complex subunit 4
DEG_SPOP_SBC_1
553:557
PLSTS
SPOP
0.8233
More...
P28562
Dual specificity protein phosphatase 1
DEG_SPOP_SBC_1
148:152
PLSTS
SPOP
0.9304
More...
Q53TQ3
INO80 complex subunit D
DEG_SPOP_SBC_1
214:218
PLSTS
SPOP
0.9858
More...
Q5THR3
EF-hand calcium-binding domain-containing protein 6
DEG_SPOP_SBC_1
119:123
PLSTS
SPOP
0.6545
More...
Q5XPI4
E3 ubiquitin-protein ligase RNF123
DEG_SPOP_SBC_1
698:702
PLSTS
SPOP
0.9944
More...
Q6UXF1
Transmembrane protein 108
DEG_SPOP_SBC_1
345:349
PLSTS
SPOP
0.979
More...
Q70CQ3
Ubiquitin carboxyl-terminal hydrolase 30
DEG_SPOP_SBC_1
466:470
PLSTS
SPOP
0.5113
More...
Q86UK5
Limbin
DEG_SPOP_SBC_1
112:116
PLSTS
SPOP
0.7993
More...
Q86Y82
Syntaxin-12
DEG_SPOP_SBC_1
90:94
PLSTS
SPOP
0.702
More...
Q8IY33
MICAL-like protein 2
DEG_SPOP_SBC_1
519:523
PLSTS
SPOP
0.9828
More...
Q8IY92
Structure-specific endonuclease subunit SLX4
DEG_SPOP_SBC_1
1448:1452
PLSTS
SPOP
0.9903
More...
Q8NEZ4
Histone-lysine N-methyltransferase 2C
DEG_SPOP_SBC_1
2661:2665
PLSTS
SPOP
0.8392
More...
Q8TEQ6
Gem-associated protein 5
DEG_SPOP_SBC_1
850:854
PLSTS
SPOP
0.9922
More...
Q96KQ4
Apoptosis-stimulating of p53 protein 1
DEG_SPOP_SBC_1
336:340
PLSTS
SPOP
0.9301
More...
Q96Q89
Kinesin-like protein KIF20B
DEG_SPOP_SBC_1
1584:1588
PLSTS
SPOP
0.9863
More...
Q99490
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
DEG_SPOP_SBC_1
1046:1050
PLSTS
SPOP
0.6945
More...
Q99570
Phosphoinositide 3-kinase regulatory subunit 4
DEG_SPOP_SBC_1
901:905
PLSTS
SPOP
0.9634
More...
Q9H2E6
Semaphorin-6A
DEG_SPOP_SBC_1
1018:1022
PLSTS
SPOP
0.9889
More...
Q9H706
GRB2-associated and regulator of MAPK protein 1
DEG_SPOP_SBC_1
542:546
PLSTS
SPOP
0.9196
More...
Q9HBL0
Tensin-1
DEG_SPOP_SBC_1
1075:1079
PLSTS
SPOP
0.9851
More...
Q9UBP5
Hairy/enhancer-of-split related with YRPW motif protein 2
DEG_SPOP_SBC_1
252:256
PLSTS
SPOP
0.7183
More...
Q6ZUB1
Spermatogenesis-associated protein 31E1
DEG_SPOP_SBC_1
1149:1153
PLSTS
SPOP
0.9944
More...
Q96HE9
Proline-rich protein 11
DEG_SPOP_SBC_1
350:354
PLSTS
SPOP
0.9951
More...
Q6ZU67
BEN domain-containing protein 4
DEG_SPOP_SBC_1
281:285
PLSTS
SPOP
0.8233
More...
Q5HYC2
Uncharacterized protein KIAA2026
DEG_SPOP_SBC_1
1617:1621
PLSTS
SPOP
0.5245
More...