DegronMD

Uniprot ID: Q86UK5

Source protein: Limbin

Source gene: EVC2

Class: DEG_SPOP_SBC_1

Location: 112:116

E3 ligase: SPOP

DEGRON score: 0.7993

ASA_SCORE: 63.58

COIL: 0.7426

CONS_SCORE: 0.2982

DSS_SCORE: 0.2026

HELIX: 0.1174

FCONS_SCORE: 0.8749

RIG_SCORE: 0.7872

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I111T	TCGA-AA-3947	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.3056
p.I111T	DO8192	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.T115A	TCGA-BR-8485	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T115A	DO47823	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.P112Q	TCGA-CM-6171	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.7035
p.P112Q	DO8151	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7035
p.S116Y	TCGA-D1-A17Q	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.712
p.S116Y	DO41903	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.712
p.E108K	TCGA-DS-A1OB	CESC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2222
p.M107I	TCGA-DU-A7TB	LGG	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1944
p.A117V	DO222967	BTCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.A117V	SIDM00216	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.A117V	ACH-000989	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.3056
p.A117V	SNU-175	large_intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.P122T	DO228974	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.L124F	DO50970	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.S116L	DO222843	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7667
p.S116L	NCI-H2347	lung	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7667
p.L113F	SIDM00216	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.587
p.L113F	SNU-175	large_intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.587
p.T115N	SIDM01183	Other Solid Cancers	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7055
p.T115N	ACH-001417	Lung Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.7055
p.T115N	UMC-11	lung	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7055
p.L103W	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.0833
p.L103W	ACH-002267	Leukemia	CCLE	PLSTS	DEG_SPOP_SBC_1	0.0833
p.L103W	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.0833
p.T115S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.6005
p.T115S	ACH-000717	Esophageal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.6005
p.T115S	COLO-680N	oesophagus	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.6005
p.G121W	SIDM01503	Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.1944
p.G121W	ACH-000844	Lung Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.1944
p.H125N	ACH-002023	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.0833
p.N119H	ACN	autonomic_ganglia	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.25
p.S121W	ZR-75-30	breast	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.1944
p.R104H	SNU-1040	large_intestine	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00167	Eyes absent homolog 2	DEG_SPOP_SBC_1	196:200	PLSTS	SPOP	0.8269	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	553:557	PLSTS	SPOP	0.8233	More...
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	148:152	PLSTS	SPOP	0.9304	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	214:218	PLSTS	SPOP	0.9858	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	119:123	PLSTS	SPOP	0.6545	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	698:702	PLSTS	SPOP	0.9944	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	345:349	PLSTS	SPOP	0.979	More...
Q70CQ3	Ubiquitin carboxyl-terminal hydrolase 30	DEG_SPOP_SBC_1	466:470	PLSTS	SPOP	0.5113	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	112:116	PLSTS	SPOP	0.7993	More...
Q86Y82	Syntaxin-12	DEG_SPOP_SBC_1	90:94	PLSTS	SPOP	0.702	More...
Q8IY33	MICAL-like protein 2	DEG_SPOP_SBC_1	519:523	PLSTS	SPOP	0.9828	More...
Q8IY92	Structure-specific endonuclease subunit SLX4	DEG_SPOP_SBC_1	1448:1452	PLSTS	SPOP	0.9903	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	2661:2665	PLSTS	SPOP	0.8392	More...
Q8TEQ6	Gem-associated protein 5	DEG_SPOP_SBC_1	850:854	PLSTS	SPOP	0.9922	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	336:340	PLSTS	SPOP	0.9301	More...
Q96Q89	Kinesin-like protein KIF20B	DEG_SPOP_SBC_1	1584:1588	PLSTS	SPOP	0.9863	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	1046:1050	PLSTS	SPOP	0.6945	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	901:905	PLSTS	SPOP	0.9634	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	1018:1022	PLSTS	SPOP	0.9889	More...
Q9H706	GRB2-associated and regulator of MAPK protein 1	DEG_SPOP_SBC_1	542:546	PLSTS	SPOP	0.9196	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1075:1079	PLSTS	SPOP	0.9851	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	252:256	PLSTS	SPOP	0.7183	More...
Q6ZUB1	Spermatogenesis-associated protein 31E1	DEG_SPOP_SBC_1	1149:1153	PLSTS	SPOP	0.9944	More...
Q96HE9	Proline-rich protein 11	DEG_SPOP_SBC_1	350:354	PLSTS	SPOP	0.9951	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	281:285	PLSTS	SPOP	0.8233	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1617:1621	PLSTS	SPOP	0.5245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTS

Degron related mutations and impact score

Drug responses associated with EVC2 mutations

All proteins holding degron of PLSTS