DegronMD - Q99490(AGAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A337S	TCGA-B5-A11N	UCEC	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.A337S	DO41458	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.R340C	TCGA-BS-A0UV	UCEC	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.3056
p.R340C	DO42793	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.3056
p.R340C	SIDM00499	Prostate Carcinoma	GDSC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.3056
p.R340C	ACH-000956	Prostate Cancer	CCLE	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.3056
p.R340C	22RV1	prostate	COSMIC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.3056
p.K836T	TCGA-D1-A17Q	UCEC	TCGA	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2778
p.K836T	TCGA-EO-A3B0	UCEC	TCGA	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2778
p.K836T	DO219773	UCEC	ICGC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2778
p.K836T	DO41903	UCEC	ICGC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2778
p.G849V	TCGA-D3-A2JC	SKCM	TCGA	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.1944
p.G849V	DO47578	SKCM	ICGC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.1944
p.Q1040R	TCGA-DI-A1BU	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.Q1040R	DO42023	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.R342H	TCGA-EO-A22R	UCEC	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8244
p.R342H	DO42713	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.8244
p.G334E	TCGA-FW-A3R5	SKCM	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1389
p.G334E	DO37406	SKCM	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.1389
p.K354E	TCGA-L5-A8NR	ESCA	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation substituting flanking lysine	0.3056
p.W359C	DO219007	BLCA	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.0556
p.L1058P	DO3412	BRCA	ICGC	PLSTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1111
p.F143L	DO222953	BTCA	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.25
p.A175T	DO8264	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1389
p.V142I	DO234305	ESAD	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.I342M	DO48215	ESCA	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.7618
p.R177G	DO233156	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.R165C	DO233173	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.8301
p.R165C	DO34801	PACA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.8301
p.P171T	DO233210	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.R141P	DO233903	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S144G	DO233908	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2222
p.R169Q	DO13929	GBM	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.G171S	DO51003	LAML	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.G171S	DO231075	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.S144T	DO231947	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2222
p.L1047M	DO229018	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.5999
p.T339N	DO229027	LICA	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2778
p.H158Q	DO52208	LIHC	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1667
p.K343N	DO23602	LUAD	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.5806
p.S133L	DO26520	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.25
p.R169G	DO26608	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.G170E	DO220877	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.D137N	DO222494	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.6932
p.H158Y	DO222516	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1667
p.L164F	DO222702	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.6981
p.S163F	DO222702	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.S842F	DO222843	MELA	ICGC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation altering degron motif	0.6871
p.A130D	DO46416	OV	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.R156C	DO32814	PAAD	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.R156H	DO220239	SARC	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1111
p.P128H	DO37571	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1111
p.G331E	DO37404	SKCM	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.0556
p.G166W	DO37438	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7825
p.V177A	DO48601	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.H158N	DO47636	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1667
p.R158L	DO229229	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1667
p.G849R	DO229221	THCA	ICGC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.1944
p.R169L	DO229245	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.S147C	DO229088	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.G166R	DO38901	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7568
p.R338Q	DO40889	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.25
p.K131N	DO43306	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.A337P	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation rewiring degron network	0.2222
p.K854E	SIDM01045	Endometrial Carcinoma	GDSC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation substituting flanking lysine	0.1667
p.K854E	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation substituting flanking lysine	0.1667
p.K854E	EN	endometrium	COSMIC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation substituting flanking lysine	0.1667
p.K836N	SIDM00534	Colorectal Carcinoma	GDSC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2778
p.K836N	ACH-000986	Colon/Colorectal Cancer	CCLE	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2778
p.K836N	HT-115	large intestine	COSMIC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2778
p.K346E	SIDM00528	Breast Carcinoma	GDSC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.591
p.K346E	ACH-000934	Breast Cancer	CCLE	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.591
p.K346E	MDA-MB-361	breast	COSMIC	DRKMLKFIS	DEG_APCC_DBOX_1	341:349	Mutation altering degron motif	0.591
p.L1047P	SIDM01660	Kidney Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.6471
p.R834M	SIDM01611	Endometrial Carcinoma	GDSC	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2222
p.R834M	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTTPSKT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.2222
p.G134V	ACH-000929	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.D147Y	KYSE-520	oesophagus	COSMIC	APSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGAP2

UniProt ID: Q99490

Entrez ID: 116986

Protein name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGAP2 in