DegronMD

Uniprot ID: Q99490

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Source gene: AGAP2

Class: DEG_SCF_FBW7_1

Location: 838:844

E3 ligase: FBXW7

DEGRON score: 0.93

ASA_SCORE: 99.7143

COIL: 0.8967

CONS_SCORE: 0.3923

DSS_SCORE: 0.7236

HELIX: 0.0579

FCONS_SCORE: 1.1787

RIG_SCORE: 0.6455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K836T	TCGA-D1-A17Q	UCEC	TCGA	LTTPSKT	DEG_SCF_FBW7_1	0.2778
p.K836T	TCGA-EO-A3B0	UCEC	TCGA	LTTPSKT	DEG_SCF_FBW7_1	0.2778
p.K836T	DO219773	UCEC	ICGC	LTTPSKT	DEG_SCF_FBW7_1	0.2778
p.K836T	DO41903	UCEC	ICGC	LTTPSKT	DEG_SCF_FBW7_1	0.2778
p.G849V	TCGA-D3-A2JC	SKCM	TCGA	LTTPSKT	DEG_SCF_FBW7_1	0.1944
p.G849V	DO47578	SKCM	ICGC	LTTPSKT	DEG_SCF_FBW7_1	0.1944
p.S842F	DO222843	MELA	ICGC	LTTPSKT	DEG_SCF_FBW7_1	0.6871
p.G849R	DO229221	THCA	ICGC	LTTPSKT	DEG_SCF_FBW7_1	0.1944
p.K854E	SIDM01045	Endometrial Carcinoma	GDSC	LTTPSKT	DEG_SCF_FBW7_1	0.1667
p.K854E	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTTPSKT	DEG_SCF_FBW7_1	0.1667
p.K854E	EN	endometrium	COSMIC	LTTPSKT	DEG_SCF_FBW7_1	0.1667
p.K836N	SIDM00534	Colorectal Carcinoma	GDSC	LTTPSKT	DEG_SCF_FBW7_1	0.2778
p.K836N	ACH-000986	Colon/Colorectal Cancer	CCLE	LTTPSKT	DEG_SCF_FBW7_1	0.2778
p.K836N	HT-115	large_intestine	COSMIC	LTTPSKT	DEG_SCF_FBW7_1	0.2778
p.R834M	SIDM01611	Endometrial Carcinoma	GDSC	LTTPSKT	DEG_SCF_FBW7_1	0.2222
p.R834M	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTTPSKT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SCF_FBW7_1	838:844	LTTPSKT	FBXW7	0.93	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons