DegronMD

Uniprot ID: Q99490

Source protein: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Source gene: AGAP2

Class: DEG_APCC_DBOX_1

Location: 341:349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5409

ASA_SCORE: 65.8111

COIL: 0.3146

CONS_SCORE: 0.3002

DSS_SCORE: 0.6075

HELIX: 0.3839

FCONS_SCORE: 1.0323

RIG_SCORE: 0.7871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A337S	TCGA-B5-A11N	UCEC	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	0.2222
p.A337S	DO41458	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.2222
p.R340C	TCGA-BS-A0UV	UCEC	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	0.3056
p.R340C	DO42793	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.3056
p.R340C	SIDM00499	Prostate Carcinoma	GDSC	DRKMLKFIS	DEG_APCC_DBOX_1	0.3056
p.R340C	ACH-000956	Prostate Cancer	CCLE	DRKMLKFIS	DEG_APCC_DBOX_1	0.3056
p.R340C	22RV1	prostate	COSMIC	DRKMLKFIS	DEG_APCC_DBOX_1	0.3056
p.R342H	TCGA-EO-A22R	UCEC	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	0.8244
p.R342H	DO42713	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.8244
p.G334E	TCGA-FW-A3R5	SKCM	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	0.1389
p.G334E	DO37406	SKCM	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.1389
p.K354E	TCGA-L5-A8NR	ESCA	TCGA	DRKMLKFIS	DEG_APCC_DBOX_1	0.3056
p.W359C	DO219007	BLCA	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.0556
p.I342M	DO48215	ESCA	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.7618
p.T339N	DO229027	LICA	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.2778
p.K343N	DO23602	LUAD	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.5806
p.G331E	DO37404	SKCM	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.0556
p.R338Q	DO40889	UCEC	ICGC	DRKMLKFIS	DEG_APCC_DBOX_1	0.25
p.A337P	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	DRKMLKFIS	DEG_APCC_DBOX_1	0.2222
p.K346E	SIDM00528	Breast Carcinoma	GDSC	DRKMLKFIS	DEG_APCC_DBOX_1	0.591
p.K346E	ACH-000934	Breast Cancer	CCLE	DRKMLKFIS	DEG_APCC_DBOX_1	0.591
p.K346E	MDA-MB-361	breast	COSMIC	DRKMLKFIS	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_APCC_DBOX_1	341:349	DRKMLKFIS	APC,CDC20,FZR1	0.5409	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons