DegronMD - Q6ZUB1(SPATA31E1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P914Q	TCGA-18-3410	LUSC	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.7035
p.P914Q	DO26456	LUSC	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.7035
p.D1142Y	TCGA-21-5784	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1389
p.D1142Y	DO27271	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1389
p.P903Q	TCGA-43-3920	LUSC	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1944
p.P903Q	DO26445	LUSC	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1944
p.S910N	TCGA-55-7283	LUAD	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.5958
p.S910N	DO23606	LUAD	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.5958
p.P923Q	TCGA-78-7161	LUAD	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1389
p.P923Q	DO223459	CLLE	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1389
p.P923Q	DO25975	LUAD	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1389
p.A1141T	TCGA-AJ-A3EL	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111
p.A1141T	DO41542	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111
p.A1141T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111
p.A1141T	ACH-002222	Leukemia	CCLE	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111
p.A1141T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111
p.P914S	TCGA-AP-A1DV	UCEC	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.6752
p.P914S	DO222415	MELA	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.6752
p.P914S	DO43186	UCEC	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.6752
p.S1151F	TCGA-AY-6196	COAD	TCGA	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation altering degron motif	0.7982
p.S1151F	DO10300	COAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation altering degron motif	0.7982
p.N901I	TCGA-BR-4184	STAD	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1389
p.N901I	DO38328	STAD	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1389
p.S910G	TCGA-CN-6012	HNSC	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.5882
p.S910G	DO15743	HNSC	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation altering degron motif	0.5882
p.T1152A	TCGA-CV-6936	HNSC	TCGA	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation altering degron motif	0.7139
p.T1152A	DO14210	HNSC	ICGC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation altering degron motif	0.7139
p.G904R	TCGA-FW-A3R5	SKCM	TCGA	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.2222
p.G904R	DO37406	SKCM	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.2222
p.V1156M	TCGA-J9-A52C	PRAD	TCGA	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.25
p.V1156M	DO51343	PRAD	ICGC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.25
p.L920P	DO233722	GACA	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.2222
p.P923S	DO231201	LUSC	ICGC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1389
p.S917N	SIDM00425	Ovarian Carcinoma	GDSC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.3056
p.P924R	SIDM00253	Neuroblastoma	GDSC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1111
p.P924R	SIDM00983	Bladder Carcinoma	GDSC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1111
p.P924R	647-V	urinary tract	COSMIC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1111
p.P924R	NB6	autonomic ganglia	COSMIC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1111
p.P924L	SIDM00967	Ovarian Carcinoma	GDSC	TTSKSVPTV	DEG_COP1_1	908:916	Mutation rewiring degron network	0.1111
p.Q1147E	SIDM00707	Non-Cancerous	GDSC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.2778
p.Q1147E	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.2778
p.Q1147E	SIDM01580	Melanoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.2778
p.M1161T	SIDM00251	Gastric Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111
p.M1161T	ACH-000949	Gastric Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111
p.M1161T	TGBC11TKB	stomach	COSMIC	PLSTS	DEG_SPOP_SBC_1	1149:1153	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA31E1

UniProt ID: Q6ZUB1

Entrez ID: 286234

Protein name: Spermatogenesis-associated protein 31E1 (Protein FAM75E1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA31E1 in