DegronMD

Uniprot ID: Q6ZUB1

Source protein: Spermatogenesis-associated protein 31E1

Source gene: SPATA31E1

Class: DEG_COP1_1

Location: 908:916

E3 ligase: COP1

DEGRON score: 0.9975

ASA_SCORE: 80.2444

COIL: 0.7471

CONS_SCORE: 0.3625

DSS_SCORE: 0.7733

HELIX: 0.0237

FCONS_SCORE: 1.0942

RIG_SCORE: 0.6218

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P914Q	TCGA-18-3410	LUSC	TCGA	TTSKSVPTV	DEG_COP1_1	0.7035
p.P914Q	DO26456	LUSC	ICGC	TTSKSVPTV	DEG_COP1_1	0.7035
p.P914S	TCGA-AP-A1DV	UCEC	TCGA	TTSKSVPTV	DEG_COP1_1	0.6752
p.P914S	DO222415	MELA	ICGC	TTSKSVPTV	DEG_COP1_1	0.6752
p.P914S	DO43186	UCEC	ICGC	TTSKSVPTV	DEG_COP1_1	0.6752
p.S910N	TCGA-55-7283	LUAD	TCGA	TTSKSVPTV	DEG_COP1_1	0.5958
p.S910N	DO23606	LUAD	ICGC	TTSKSVPTV	DEG_COP1_1	0.5958
p.S910G	TCGA-CN-6012	HNSC	TCGA	TTSKSVPTV	DEG_COP1_1	0.5882
p.S910G	DO15743	HNSC	ICGC	TTSKSVPTV	DEG_COP1_1	0.5882
p.S917N	SIDM00425	Ovarian Carcinoma	GDSC	TTSKSVPTV	DEG_COP1_1	0.3056
p.G904R	TCGA-FW-A3R5	SKCM	TCGA	TTSKSVPTV	DEG_COP1_1	0.2222
p.G904R	DO37406	SKCM	ICGC	TTSKSVPTV	DEG_COP1_1	0.2222
p.L920P	DO233722	GACA	ICGC	TTSKSVPTV	DEG_COP1_1	0.2222
p.P903Q	TCGA-43-3920	LUSC	TCGA	TTSKSVPTV	DEG_COP1_1	0.1944
p.P903Q	DO26445	LUSC	ICGC	TTSKSVPTV	DEG_COP1_1	0.1944
p.P923Q	TCGA-78-7161	LUAD	TCGA	TTSKSVPTV	DEG_COP1_1	0.1389
p.P923Q	DO223459	CLLE	ICGC	TTSKSVPTV	DEG_COP1_1	0.1389
p.P923Q	DO25975	LUAD	ICGC	TTSKSVPTV	DEG_COP1_1	0.1389
p.N901I	TCGA-BR-4184	STAD	TCGA	TTSKSVPTV	DEG_COP1_1	0.1389
p.N901I	DO38328	STAD	ICGC	TTSKSVPTV	DEG_COP1_1	0.1389
p.P923S	DO231201	LUSC	ICGC	TTSKSVPTV	DEG_COP1_1	0.1389
p.P924R	SIDM00253	Neuroblastoma	GDSC	TTSKSVPTV	DEG_COP1_1	0.1111
p.P924R	SIDM00983	Bladder Carcinoma	GDSC	TTSKSVPTV	DEG_COP1_1	0.1111
p.P924R	647-V	urinary_tract	COSMIC	TTSKSVPTV	DEG_COP1_1	0.1111
p.P924R	NB6	autonomic_ganglia	COSMIC	TTSKSVPTV	DEG_COP1_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZUB1	Spermatogenesis-associated protein 31E1	DEG_COP1_1	908:916	TTSKSVPTV	COP1	0.9975	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons