DegronMD - Q53TQ3(INO80D)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S818I	TCGA-04-1649	OV	TCGA	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.0556
p.S818I	DO32467	OV	ICGC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.0556
p.A223S	TCGA-56-8628	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.A223S	DO45433	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.D910N	TCGA-5L-AAT1	BRCA	TCGA	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.1111
p.D910N	DO219594	BRCA	ICGC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.1111
p.T145N	TCGA-73-4668	LUAD	TCGA	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.3056
p.T145N	DO23961	LUAD	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.3056
p.A857S	TCGA-75-6214	LUAD	TCGA	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1389
p.A857S	DO24830	LUAD	ICGC	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1389
p.S850L	TCGA-A5-A0G2	UCEC	TCGA	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.7667
p.S850L	DO41235	UCEC	ICGC	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.7667
p.R587W	TCGA-A5-A0VP	UCEC	TCGA	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation rewiring degron network	0.2778
p.R587W	DO42600	UCEC	ICGC	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation rewiring degron network	0.2778
p.P221H	TCGA-B5-A11E	UCEC	TCGA	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.25
p.P221H	DO41644	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.25
p.S925L	TCGA-B5-A1MR	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S925L	DO220903	MELA	ICGC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S925L	DO41758	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.L945F	TCGA-B5-A1MX	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.25
p.L945F	TCGA-B5-A1MX	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2778
p.L945F	DO41999	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.25
p.L945F	DO41999	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2778
p.T930I	TCGA-B5-A1MX	UCEC	TCGA	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.1667
p.T930I	TCGA-B5-A1MX	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.1389
p.T930I	TCGA-B5-A1MX	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1944
p.T930I	TCGA-B5-A1MX	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.0833
p.T930I	DO41999	UCEC	ICGC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.1667
p.T930I	DO41999	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.1389
p.T930I	DO41999	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1944
p.T930I	DO41999	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.0833
p.H820L	TCGA-BG-A222	UCEC	TCGA	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.1111
p.H820L	DO42977	UCEC	ICGC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.1111
p.T920M	TCGA-CG-4465	STAD	TCGA	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation altering degron motif	0.7423
p.T920M	DO38627	STAD	ICGC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation altering degron motif	0.7423
p.G135R	TCGA-D5-6534	COAD	TCGA	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.3056
p.G135R	DO10718	COAD	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.3056
p.S915Y	TCGA-E9-A1R7	BRCA	TCGA	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.25
p.S915Y	TCGA-E9-A1R7	BRCA	TCGA	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1667
p.S915Y	DO1978	BRCA	ICGC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.25
p.S915Y	DO1978	BRCA	ICGC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1667
p.D831Y	TCGA-ER-A3EV	SKCM	TCGA	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation altering degron motif	0.7325
p.D831Y	DO48597	SKCM	ICGC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation altering degron motif	0.7325
p.P946L	TCGA-FI-A2D6	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.2222
p.P946L	TCGA-FI-A2D6	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.P946L	DO233869	GACA	ICGC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.2222
p.P946L	DO233869	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.P946L	DO43867	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.2222
p.P946L	DO43867	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.P946L	ACH-000999	Colon/Colorectal Cancer	CCLE	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.2222
p.P946L	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.P846L	TCGA-FW-A3R5	SKCM	TCGA	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.7582
p.P846L	DO37406	SKCM	ICGC	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation altering degron motif	0.7582
p.A223V	TCGA-HT-7473	LGG	TCGA	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.A223V	DO22571	LGG	ICGC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.M856V	TCGA-HU-A4H0	STAD	TCGA	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1667
p.M856V	DO47785	STAD	ICGC	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.1667
p.S823P	TCGA-JY-A6FH	ESCA	TCGA	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.1944
p.L913V	TCGA-LN-A4A2	ESCA	TCGA	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.1944
p.L913V	TCGA-LN-A4A2	ESCA	TCGA	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.A136V	TCGA-VQ-A8P2	STAD	TCGA	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation altering degron motif	0.5825
p.A136V	DO51761	STAD	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation altering degron motif	0.5825
p.H829Q	DO52456	COCA	ICGC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation altering degron motif	0.647
p.G911E	DO234235	ESAD	ICGC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.1389
p.G911E	DO234235	ESAD	ICGC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0556
p.R137M	DO233168	GACA	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation altering degron motif	0.8632
p.A604D	DO228948	LICA	ICGC	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation rewiring degron network	0.0833
p.P205T	DO228952	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.0833
p.H211Q	DO229037	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.25
p.A152D	DO229045	LICA	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.1111
p.H842R	DO230961	LUSC	ICGC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.2222
p.H842R	DO230961	LUSC	ICGC	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.2222
p.H842R	DO224594	LUSC	ICGC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.2222
p.H842R	DO224594	LUSC	ICGC	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.2222
p.G947V	DO231047	LUSC	ICGC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.1944
p.G947V	DO231047	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2222
p.P932T	DO232761	PBCA	ICGC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.1111
p.P932T	DO232761	PBCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.1944
p.P932T	DO232761	PBCA	ICGC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1389
p.P932T	DO232761	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1389
p.A935T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.2778
p.A935T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0556
p.A935T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2222
p.A935T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.2778
p.A935T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0556
p.A935T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.2222
p.P134H	SIDM00789	Colorectal Carcinoma	GDSC	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.2778
p.P134H	ACH-000997	Colon/Colorectal Cancer	CCLE	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.2778
p.P134H	ACH-001061	Colon/Colorectal Cancer	CCLE	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.2778
p.P134H	HCT-15	large intestine	COSMIC	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.2778
p.T936I	SIDM00007	Other Solid Cancers	GDSC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.3056
p.T936I	SIDM00007	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.T936I	ACH-001550	Skin Cancer	CCLE	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.3056
p.T936I	ACH-001550	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.T936I	MCC13	skin	COSMIC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.3056
p.T936I	MCC13	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.E928V	SIDM01071	Small Cell Lung Carcinoma	GDSC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.2222
p.E928V	SIDM01071	Small Cell Lung Carcinoma	GDSC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.0833
p.E928V	SIDM01071	Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.25
p.E928V	ACH-000515	Lung Cancer	CCLE	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.2222
p.E928V	ACH-000515	Lung Cancer	CCLE	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.0833
p.E928V	ACH-000515	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.25
p.E928V	HCC-33	lung	COSMIC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.2222
p.E928V	HCC-33	lung	COSMIC	VTPSSS	DEG_SCF_FBW7_1	937:942	Mutation rewiring degron network	0.0833
p.E928V	HCC-33	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.25
p.P580S	SIDM00660	Colorectal Carcinoma	GDSC	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation rewiring degron network	0.0833
p.P580S	ACH-000985	Colon/Colorectal Cancer	CCLE	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation rewiring degron network	0.0833
p.P580S	LS-411N	large intestine	COSMIC	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation rewiring degron network	0.0833
p.S818C	SIDM00869	Non-Cancerous	GDSC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.0556
p.S818C	SIDM01133	Other Solid Cancers	GDSC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.0556
p.S818C	SIDM01635	Glioblastoma	GDSC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation rewiring degron network	0.0556
p.P838L	SIDM01060	Melanoma	GDSC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation altering degron motif	0.6471
p.P838L	ACH-000882	Skin Cancer	CCLE	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation altering degron motif	0.6471
p.P838L	IGR-1	skin	COSMIC	SHYDSEHVPSP	DEG_COP1_1	828:838	Mutation altering degron motif	0.6471
p.P214S	SIDM00853	Other Sarcomas	GDSC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.6752
p.P214S	ACH-000835	Sarcoma	CCLE	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.6752
p.P214S	GCT	soft tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.6752
p.S210Y	SIDM00251	Gastric Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.2222
p.S210Y	ACH-000949	Gastric Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.2222
p.S210Y	TGBC11TKB	stomach	COSMIC	PLSTS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.2222
p.G908S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.0556
p.G908S	ACH-000938	Leukemia	CCLE	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.0556
p.G908S	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.0556
p.T591M	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation altering degron motif	0.7423
p.T591M	ACH-000942	Leukemia	CCLE	PSTPELS	DEG_SCF_FBW7_1	589:595	Mutation altering degron motif	0.7423
p.Y851C	ACH-000961	Endometrial/Uterine Cancer	CCLE	PHTTS	DEG_SPOP_SBC_1	846:850	Mutation rewiring degron network	0.3056
p.A909T	ACH-001100		CCLE	LSTPPTT	DEG_SCF_FBW7_1	918:924	Mutation rewiring degron network	0.0833
p.R137W	ACH-001852	Bile Duct Cancer	CCLE	ARVPLHYLE	DEG_APCC_DBOX_1	136:144	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INO80D

UniProt ID: Q53TQ3

Entrez ID: 54891

Protein name: INO80 complex subunit D

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INO80D in