DegronMD

Uniprot ID: Q53TQ3

Source protein: INO80 complex subunit D

Source gene: INO80D

Class: DEG_SCF_FBW7_1

Location: 918:924

E3 ligase: FBXW7

DEGRON score: 0.9955

ASA_SCORE: 78.2714

COIL: 0.9349

CONS_SCORE: 0

DSS_SCORE: 0.6337

HELIX: 0.0204

FCONS_SCORE: 0

RIG_SCORE: 0.6112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D910N	TCGA-5L-AAT1	BRCA	TCGA	LSTPPTT	DEG_SCF_FBW7_1	0.1111
p.D910N	DO219594	BRCA	ICGC	LSTPPTT	DEG_SCF_FBW7_1	0.1111
p.T930I	TCGA-B5-A1MX	UCEC	TCGA	LSTPPTT	DEG_SCF_FBW7_1	0.1667
p.T930I	DO41999	UCEC	ICGC	LSTPPTT	DEG_SCF_FBW7_1	0.1667
p.T920M	TCGA-CG-4465	STAD	TCGA	LSTPPTT	DEG_SCF_FBW7_1	0.7423
p.T920M	DO38627	STAD	ICGC	LSTPPTT	DEG_SCF_FBW7_1	0.7423
p.S915Y	TCGA-E9-A1R7	BRCA	TCGA	LSTPPTT	DEG_SCF_FBW7_1	0.25
p.S915Y	DO1978	BRCA	ICGC	LSTPPTT	DEG_SCF_FBW7_1	0.25
p.L913V	TCGA-LN-A4A2	ESCA	TCGA	LSTPPTT	DEG_SCF_FBW7_1	0.1944
p.G911E	DO234235	ESAD	ICGC	LSTPPTT	DEG_SCF_FBW7_1	0.1389
p.P932T	DO232761	PBCA	ICGC	LSTPPTT	DEG_SCF_FBW7_1	0.1111
p.E928V	SIDM01071	Small Cell Lung Carcinoma	GDSC	LSTPPTT	DEG_SCF_FBW7_1	0.2222
p.E928V	ACH-000515	Lung Cancer	CCLE	LSTPPTT	DEG_SCF_FBW7_1	0.2222
p.E928V	HCC-33	lung	COSMIC	LSTPPTT	DEG_SCF_FBW7_1	0.2222
p.G908S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LSTPPTT	DEG_SCF_FBW7_1	0.0556
p.G908S	ACH-000938	Leukemia	CCLE	LSTPPTT	DEG_SCF_FBW7_1	0.0556
p.G908S	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPPTT	DEG_SCF_FBW7_1	0.0556
p.A909T	ACH-001100		CCLE	LSTPPTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SCF_FBW7_1	918:924	LSTPPTT	FBXW7	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons