DegronMD

Uniprot ID: Q53TQ3

Source protein: INO80 complex subunit D

Source gene: INO80D

Class: DEG_APCC_DBOX_1

Location: 136:144

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8441

ASA_SCORE: 83.1

COIL: 0.698

CONS_SCORE: 0.3713

DSS_SCORE: 0.4045

HELIX: 0.1678

FCONS_SCORE: 0.907

RIG_SCORE: 0.7448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T145N	TCGA-73-4668	LUAD	TCGA	ARVPLHYLE	DEG_APCC_DBOX_1	0.3056
p.T145N	DO23961	LUAD	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	0.3056
p.G135R	TCGA-D5-6534	COAD	TCGA	ARVPLHYLE	DEG_APCC_DBOX_1	0.3056
p.G135R	DO10718	COAD	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	0.3056
p.A136V	TCGA-VQ-A8P2	STAD	TCGA	ARVPLHYLE	DEG_APCC_DBOX_1	0.5825
p.A136V	DO51761	STAD	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	0.5825
p.R137M	DO233168	GACA	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	0.8632
p.A152D	DO229045	LICA	ICGC	ARVPLHYLE	DEG_APCC_DBOX_1	0.1111
p.P134H	SIDM00789	Colorectal Carcinoma	GDSC	ARVPLHYLE	DEG_APCC_DBOX_1	0.2778
p.P134H	ACH-000997	Colon/Colorectal Cancer	CCLE	ARVPLHYLE	DEG_APCC_DBOX_1	0.2778
p.P134H	ACH-001061	Colon/Colorectal Cancer	CCLE	ARVPLHYLE	DEG_APCC_DBOX_1	0.2778
p.P134H	HCT-15	large_intestine	COSMIC	ARVPLHYLE	DEG_APCC_DBOX_1	0.2778
p.R137W	ACH-001852	Bile Duct Cancer	CCLE	ARVPLHYLE	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_APCC_DBOX_1	136:144	ARVPLHYLE	APC,CDC20,FZR1	0.8441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons