DegronMD

Uniprot ID: Q53TQ3

Source protein: INO80 complex subunit D

Source gene: INO80D

Class: DEG_SCF_FBW7_1

Location: 937:942

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 70.9833

COIL: 0.913

CONS_SCORE: 0

DSS_SCORE: 0.569

HELIX: 0.0487

FCONS_SCORE: 0

RIG_SCORE: 0.676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L945F	TCGA-B5-A1MX	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.25
p.L945F	DO41999	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.25
p.T930I	TCGA-B5-A1MX	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.1389
p.T930I	DO41999	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1389
p.P946L	TCGA-FI-A2D6	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.2222
p.P946L	DO233869	GACA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.2222
p.P946L	DO43867	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.2222
p.P946L	ACH-000999	Colon/Colorectal Cancer	CCLE	VTPSSS	DEG_SCF_FBW7_1	0.2222
p.G947V	DO231047	LUSC	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.P932T	DO232761	PBCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.A935T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.2778
p.A935T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.2778
p.T936I	SIDM00007	Other Solid Cancers	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.T936I	ACH-001550	Skin Cancer	CCLE	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.T936I	MCC13	skin	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.E928V	SIDM01071	Small Cell Lung Carcinoma	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.0833
p.E928V	ACH-000515	Lung Cancer	CCLE	VTPSSS	DEG_SCF_FBW7_1	0.0833
p.E928V	HCC-33	lung	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SCF_FBW7_1	937:942	VTPSSS	FBXW7	0.9957	More...
Q8IX15	Homeobox and leucine zipper protein Homez	DEG_SCF_FBW7_1	281:286	VTPSSS	FBXW7	0.9457	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3875:3880	VTPSSS	FBXW7	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons