DegronMD

Uniprot ID: Q8IX15

Source protein: Homeobox and leucine zipper protein Homez

Source gene: HOMEZ

Class: DEG_SCF_FBW7_1

Location: 281:286

E3 ligase: FBXW7

DEGRON score: 0.9457

ASA_SCORE: 89.5833

COIL: 0.9647

CONS_SCORE: 0.6779

DSS_SCORE: 0.5134

HELIX: 0.0183

FCONS_SCORE: 1.0352

RIG_SCORE: 0.5564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T288I	TCGA-BS-A0UV	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.2778
p.T288I	DO42793	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.2778
p.S289Y	TCGA-EE-A29Q	SKCM	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.25
p.S284F	TCGA-EK-A3GK	CESC	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.6871
p.E275D	TCGA-ER-A19B	SKCM	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.1667
p.T282A	TCGA-F7-A624	HNSC	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.7139
p.S286F	DO49964	CESC	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.7982
p.T284A	DO44440	HNSC	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.7139
p.S273C	DO228313	LICA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1111
p.S280T	DO51047	PRAD	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.S291Y	DO37866	SKCM	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.E277D	DO47491	SKCM	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SCF_FBW7_1	937:942	VTPSSS	FBXW7	0.9957	More...
Q8IX15	Homeobox and leucine zipper protein Homez	DEG_SCF_FBW7_1	281:286	VTPSSS	FBXW7	0.9457	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3875:3880	VTPSSS	FBXW7	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons