DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3875:3880

E3 ligase: FBXW7

DEGRON score: 0.9893

ASA_SCORE: 86.4833

COIL: 0.9503

CONS_SCORE: 0.2408

DSS_SCORE: 0.6396

HELIX: 0.0093

FCONS_SCORE: 0.8984

RIG_SCORE: 0.6843

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3886M	TCGA-A6-A566	COAD	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.1667
p.T3886M	DO225077	BRCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1667
p.T3874K	TCGA-BH-A42V	BRCA	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.W3890R	TCGA-C4-A0EZ	BLCA	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.0556
p.W3890C	TCGA-DR-A0ZM	CESC	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.0556
p.V3889M	TCGA-EE-A3J5	SKCM	TCGA	VTPSSS	DEG_SCF_FBW7_1	0.0833
p.R3888S	DO225276	BRCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1111
p.R3888S	DO224802	BRCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1111
p.T3877K	DO44129	BRCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.7306
p.T3889M	DO44092	COAD	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.0833
p.T3870A	DO8842	COAD	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.T3871I	DO230347	COCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.2222
p.T3872A	DO223071	ESCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.25
p.T3871S	DO51814	LGG	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.2222
p.S3883I	DO229018	LICA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.25
p.P3890T	DO49113	PACA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.0556
p.P3890T	DO228762	PRAD	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.0556
p.R3888H	DO227933	PBCA	ICGC	VTPSSS	DEG_SCF_FBW7_1	0.1111
p.T3870N	SIDM00845	Burkitt's Lymphoma	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.T3870N	SIDM00846	Cervical Carcinoma	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.T3870N	SIDM00760	Small Cell Lung Carcinoma	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.T3870N	SIDM01525	Acute Myeloid Leukemia	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.T3874I	SIDM00150	Colorectal Carcinoma	GDSC	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.T3874I	ACH-000969	Colon/Colorectal Cancer	CCLE	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.T3874I	KM12	large_intestine	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.3056
p.R3885S	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	OV-17R	ovary	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	HPAC	pancreas	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	GCT	soft_tissue	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	NCI-H2444	lung	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	U-118-MG	central_nervous_system	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	U-87-MG	central_nervous_system	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	HCC202	breast	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.R3885S	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.1944
p.V3875A	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSSS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SCF_FBW7_1	937:942	VTPSSS	FBXW7	0.9957	More...
Q8IX15	Homeobox and leucine zipper protein Homez	DEG_SCF_FBW7_1	281:286	VTPSSS	FBXW7	0.9457	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3875:3880	VTPSSS	FBXW7	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPSSS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of VTPSSS