DegronMD - Q8IX15(HOMEZ)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A322S	TCGA-55-7910	LUAD	TCGA	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation rewiring degron network	0.3056
p.A322S	DO23669	LUAD	ICGC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation rewiring degron network	0.3056
p.E450G	TCGA-56-A62T	LUSC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.0833
p.P425H	TCGA-B5-A0JR	UCEC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.0556
p.P425H	DO41791	UCEC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.0556
p.T288I	TCGA-BS-A0UV	UCEC	TCGA	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.2778
p.T288I	TCGA-BS-A0UV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.3056
p.T288I	DO42793	UCEC	ICGC	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.2778
p.T288I	DO42793	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.3056
p.R443S	TCGA-CR-7388	HNSC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2778
p.R443S	DO14284	HNSC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2778
p.P425L	TCGA-CV-7568	HNSC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.0556
p.T442A	TCGA-D1-A17U	UCEC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.3056
p.D432H	TCGA-DK-AA71	BLCA	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.25
p.D432H	DO219010	BLCA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.25
p.S289Y	TCGA-EE-A29Q	SKCM	TCGA	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.25
p.S289Y	TCGA-EE-A29Q	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.2778
p.S284F	TCGA-EK-A3GK	CESC	TCGA	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation altering degron motif	0.6871
p.S284F	TCGA-EK-A3GK	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.6871
p.E275D	TCGA-ER-A19B	SKCM	TCGA	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.1667
p.E275D	TCGA-ER-A19B	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1111
p.T282A	TCGA-F7-A624	HNSC	TCGA	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation altering degron motif	0.7139
p.P428H	TCGA-GN-A265	SKCM	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.1389
p.P428H	DO37491	SKCM	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.1389
p.L445F	TCGA-XF-A9T5	BLCA	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.2222
p.P440Q	TCGA-XK-AAIW	PRAD	TCGA	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation altering degron motif	0.5924
p.P440Q	DO51407	PRAD	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation altering degron motif	0.5924
p.P325L	TCGA-YG-AA3O	SKCM	TCGA	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation altering degron motif	0.6471
p.L447F	DO51925	BLCA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.1667
p.S286F	DO49964	CESC	ICGC	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation altering degron motif	0.7982
p.S286F	DO49964	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.7982
p.T284A	DO44440	HNSC	ICGC	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation altering degron motif	0.7139
p.T284A	DO44440	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation altering degron motif	0.7139
p.P427L	DO14160	HNSC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.1111
p.S273C	DO228313	LICA	ICGC	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.1111
p.S273C	DO228313	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.0556
p.P430S	DO222702	MELA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.1944
p.A425T	DO228138	PBCA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation rewiring degron network	0.0556
p.S280T	DO51047	PRAD	ICGC	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.3056
p.S280T	DO51047	PRAD	ICGC	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.25
p.S291Y	DO37866	SKCM	ICGC	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.1944
p.S291Y	DO37866	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.2222
p.E277D	DO47491	SKCM	ICGC	VTPSSS	DEG_SCF_FBW7_1	281:286	Mutation rewiring degron network	0.2222
p.E277D	DO47491	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1667
p.P327L	DO51299	SKCM	ICGC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation altering degron motif	0.7582
p.T444A	DO41887	UCEC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	435:441	Mutation blocking phosphorylation signal	0.6944
p.R336Q	SIDM00792	Small Cell Lung Carcinoma	GDSC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation rewiring degron network	0.1111
p.R336Q	SIDM01522	B-Lymphoblastic Leukemia	GDSC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation rewiring degron network	0.1111
p.L323V	SIDM00968	Ovarian Carcinoma	GDSC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation altering degron motif	0.5654
p.L323V	ACH-002140	Ovarian Cancer	CCLE	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation altering degron motif	0.5654
p.L323V	Hey	ovary	COSMIC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation altering degron motif	0.5654
p.R336L	SIDM00467	Acute Myeloid Leukemia	GDSC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation rewiring degron network	0.1111
p.R336L	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation rewiring degron network	0.1111
p.R338L	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation rewiring degron network	0.0556
p.L325V	Hey	ovary	COSMIC	LPPHLE	LIG_APCC_ABBA_1	323:328	Mutation altering degron motif	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOMEZ

UniProt ID: Q8IX15

Entrez ID: 57594

Protein name: Homeobox and leucine zipper protein Homez (Homeodomain leucine zipper-containing factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOMEZ in