DegronMD

Uniprot ID: Q8IX15

Source protein: Homeobox and leucine zipper protein Homez

Source gene: HOMEZ

Class: LIG_APCC_ABBA_1

Location: 323:328

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9958

ASA_SCORE: 90.85

COIL: 0.9257

CONS_SCORE: 0.839

DSS_SCORE: 0.625

HELIX: 0.0352

FCONS_SCORE: 1.206

RIG_SCORE: 0.6501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A322S	TCGA-55-7910	LUAD	TCGA	LPPHLE	LIG_APCC_ABBA_1	0.3056
p.A322S	DO23669	LUAD	ICGC	LPPHLE	LIG_APCC_ABBA_1	0.3056
p.P325L	TCGA-YG-AA3O	SKCM	TCGA	LPPHLE	LIG_APCC_ABBA_1	0.6471
p.P327L	DO51299	SKCM	ICGC	LPPHLE	LIG_APCC_ABBA_1	0.7582
p.R336Q	SIDM00792	Small Cell Lung Carcinoma	GDSC	LPPHLE	LIG_APCC_ABBA_1	0.1111
p.R336Q	SIDM01522	B-Lymphoblastic Leukemia	GDSC	LPPHLE	LIG_APCC_ABBA_1	0.1111
p.L323V	SIDM00968	Ovarian Carcinoma	GDSC	LPPHLE	LIG_APCC_ABBA_1	0.5654
p.L323V	ACH-002140	Ovarian Cancer	CCLE	LPPHLE	LIG_APCC_ABBA_1	0.5654
p.L323V	Hey	ovary	COSMIC	LPPHLE	LIG_APCC_ABBA_1	0.5654
p.R336L	SIDM00467	Acute Myeloid Leukemia	GDSC	LPPHLE	LIG_APCC_ABBA_1	0.1111
p.R336L	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	LPPHLE	LIG_APCC_ABBA_1	0.1111
p.R338L	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	LPPHLE	LIG_APCC_ABBA_1	0.0556
p.L325V	Hey	ovary	COSMIC	LPPHLE	LIG_APCC_ABBA_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX15	Homeobox and leucine zipper protein Homez	LIG_APCC_ABBA_1	323:328	LPPHLE	APC,CDC20,FZR1	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons