DegronMD

Uniprot ID: Q8IX15

Source protein: Homeobox and leucine zipper protein Homez

Source gene: HOMEZ

Class: DEG_SCF_FBW7_1

Location: 435:441

E3 ligase: FBXW7

DEGRON score: 0.9305

ASA_SCORE: 86.7143

COIL: 0.9693

CONS_SCORE: 0.5269

DSS_SCORE: 0.749

HELIX: 0.0126

FCONS_SCORE: 0.838

RIG_SCORE: 0.5576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E450G	TCGA-56-A62T	LUSC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.0833
p.P425H	TCGA-B5-A0JR	UCEC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.0556
p.P425H	DO41791	UCEC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.0556
p.R443S	TCGA-CR-7388	HNSC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.2778
p.R443S	DO14284	HNSC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.2778
p.P425L	TCGA-CV-7568	HNSC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.0556
p.T442A	TCGA-D1-A17U	UCEC	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.3056
p.D432H	TCGA-DK-AA71	BLCA	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.25
p.D432H	DO219010	BLCA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.25
p.P428H	TCGA-GN-A265	SKCM	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.1389
p.P428H	DO37491	SKCM	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.1389
p.L445F	TCGA-XF-A9T5	BLCA	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.2222
p.P440Q	TCGA-XK-AAIW	PRAD	TCGA	IPTPPPS	DEG_SCF_FBW7_1	0.5924
p.P440Q	DO51407	PRAD	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.5924
p.L447F	DO51925	BLCA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.1667
p.P427L	DO14160	HNSC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.1111
p.P430S	DO222702	MELA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.1944
p.A425T	DO228138	PBCA	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.0556
p.T444A	DO41887	UCEC	ICGC	IPTPPPS	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX15	Homeobox and leucine zipper protein Homez	DEG_SCF_FBW7_1	435:441	IPTPPPS	FBXW7	0.9305	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons