DegronMD

Uniprot ID: Q53TQ3

Source protein: INO80 complex subunit D

Source gene: INO80D

Class: DEG_COP1_1

Location: 828:838

E3 ligase: COP1

DEGRON score: 0.9924

ASA_SCORE: 72.6

COIL: 0.8546

CONS_SCORE: 0.3948

DSS_SCORE: 0.686

HELIX: 0.0854

FCONS_SCORE: 1.0752

RIG_SCORE: 0.5442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S818I	TCGA-04-1649	OV	TCGA	SHYDSEHVPSP	DEG_COP1_1	0.0556
p.S818I	DO32467	OV	ICGC	SHYDSEHVPSP	DEG_COP1_1	0.0556
p.H820L	TCGA-BG-A222	UCEC	TCGA	SHYDSEHVPSP	DEG_COP1_1	0.1111
p.H820L	DO42977	UCEC	ICGC	SHYDSEHVPSP	DEG_COP1_1	0.1111
p.D831Y	TCGA-ER-A3EV	SKCM	TCGA	SHYDSEHVPSP	DEG_COP1_1	0.7325
p.D831Y	DO48597	SKCM	ICGC	SHYDSEHVPSP	DEG_COP1_1	0.7325
p.S823P	TCGA-JY-A6FH	ESCA	TCGA	SHYDSEHVPSP	DEG_COP1_1	0.1944
p.H829Q	DO52456	COCA	ICGC	SHYDSEHVPSP	DEG_COP1_1	0.647
p.H842R	DO230961	LUSC	ICGC	SHYDSEHVPSP	DEG_COP1_1	0.2222
p.H842R	DO224594	LUSC	ICGC	SHYDSEHVPSP	DEG_COP1_1	0.2222
p.S818C	SIDM00869	Non-Cancerous	GDSC	SHYDSEHVPSP	DEG_COP1_1	0.0556
p.S818C	SIDM01133	Other Solid Cancers	GDSC	SHYDSEHVPSP	DEG_COP1_1	0.0556
p.S818C	SIDM01635	Glioblastoma	GDSC	SHYDSEHVPSP	DEG_COP1_1	0.0556
p.P838L	SIDM01060	Melanoma	GDSC	SHYDSEHVPSP	DEG_COP1_1	0.6471
p.P838L	ACH-000882	Skin Cancer	CCLE	SHYDSEHVPSP	DEG_COP1_1	0.6471
p.P838L	IGR-1	skin	COSMIC	SHYDSEHVPSP	DEG_COP1_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_COP1_1	828:838	SHYDSEHVPSP	COP1	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons