DegronMD

Uniprot ID: Q53TQ3

Source protein: INO80 complex subunit D

Source gene: INO80D

Class: DEG_SCF_FBW7_1

Location: 589:595

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 81.4286

COIL: 0.9279

CONS_SCORE: 0.4924

DSS_SCORE: 0.6489

HELIX: 0.0359

FCONS_SCORE: 1.1689

RIG_SCORE: 0.6103

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R587W	TCGA-A5-A0VP	UCEC	TCGA	PSTPELS	DEG_SCF_FBW7_1	0.2778
p.R587W	DO42600	UCEC	ICGC	PSTPELS	DEG_SCF_FBW7_1	0.2778
p.A604D	DO228948	LICA	ICGC	PSTPELS	DEG_SCF_FBW7_1	0.0833
p.P580S	SIDM00660	Colorectal Carcinoma	GDSC	PSTPELS	DEG_SCF_FBW7_1	0.0833
p.P580S	ACH-000985	Colon/Colorectal Cancer	CCLE	PSTPELS	DEG_SCF_FBW7_1	0.0833
p.P580S	LS-411N	large_intestine	COSMIC	PSTPELS	DEG_SCF_FBW7_1	0.0833
p.T591M	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PSTPELS	DEG_SCF_FBW7_1	0.7423
p.T591M	ACH-000942	Leukemia	CCLE	PSTPELS	DEG_SCF_FBW7_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SCF_FBW7_1	589:595	PSTPELS	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons