DegronMD - Q8NEZ4(KMT2C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T814S	TCGA-12-1093	GBM	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.T814S	DO14097	GBM	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.A803S	TCGA-17-Z014	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7588
p.P2438S	TCGA-22-5481	LUSC	TCGA	PPPY	ITCH	2436:2439	Mutation altering degron motif	0.5641
p.P2438S	DO27160	LUSC	ICGC	PPPY	ITCH	2436:2439	Mutation altering degron motif	0.5641
p.P2101A	TCGA-23-1110	OV	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.25
p.P2101A	DO29398	OV	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.25
p.P3898A	TCGA-2F-A9KO	BLCA	TCGA	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.6392
p.G2136V	TCGA-2W-A8YY	CESC	TCGA	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.3056
p.G2136V	DO223732	CESC	ICGC	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.3056
p.Q560L	TCGA-43-8115	LUSC	TCGA	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.0556
p.Q560L	DO26440	LUSC	ICGC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.0556
p.T3634P	TCGA-44-8120	LUAD	TCGA	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation altering degron motif	0.7031
p.T3634P	DO45402	LUAD	ICGC	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation altering degron motif	0.7031
p.P3633Q	TCGA-44-8120	LUAD	TCGA	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation altering degron motif	0.5924
p.P3633Q	DO45402	LUAD	ICGC	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation altering degron motif	0.5924
p.I2082V	TCGA-46-3768	LUSC	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1667
p.I2082V	DO26466	LUSC	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1667
p.M796L	TCGA-53-7626	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.M796L	DO23774	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.M796L	LN-405	central nervous system	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.P813A	TCGA-67-3771	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1667
p.P813A	DO25797	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1667
p.M812I	TCGA-73-A9RS	LUAD	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.M812I	TCGA-CN-A63W	HNSC	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.M812I	TCGA-V1-A9OT	PRAD	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.M812I	DO49031	HNSC	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.M812I	DO51193	LUAD	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.M812I	DO219385	PRAD	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.G756R	TCGA-74-6577	GBM	TCGA	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.0556
p.G756R	DO13941	GBM	ICGC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.0556
p.Y2439C	TCGA-91-6829	LUAD	TCGA	PPPY	ITCH	2436:2439	Mutation altering degron motif	0.7087
p.Y2439C	DO23564	LUAD	ICGC	PPPY	ITCH	2436:2439	Mutation altering degron motif	0.7087
p.D2092Y	TCGA-97-7547	LUAD	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6214
p.D2092Y	DO23594	LUAD	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6214
p.S2160F	TCGA-A5-A0G2	UCEC	TCGA	NTDPYSQPP	CBL_PTK	2155:2163	Mutation altering degron motif	0.7982
p.S2160F	DO41235	UCEC	ICGC	NTDPYSQPP	CBL_PTK	2155:2163	Mutation altering degron motif	0.7982
p.T1839M	TCGA-A5-A0G2	UCEC	TCGA	PPSTPTST	DEG_SCF_FBW7_1	1834:1841	Mutation altering degron motif	0.6312
p.T1839M	TCGA-A5-A0G2	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	1838:1842	Mutation altering degron motif	0.6312
p.T1839M	DO41235	UCEC	ICGC	PPSTPTST	DEG_SCF_FBW7_1	1834:1841	Mutation altering degron motif	0.6312
p.T1839M	DO41235	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	1838:1842	Mutation altering degron motif	0.6312
p.E3639V	TCGA-A5-A2K5	UCEC	TCGA	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.3056
p.E3639V	DO41379	UCEC	ICGC	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.3056
p.S793L	TCGA-A5-A2K7	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.0556
p.S793L	TCGA-AZ-4315	COAD	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.0556
p.S793L	DO8842	COAD	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.0556
p.S793L	DO41271	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.0556
p.S793L	SIDM01588	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.0556
p.S793L	MCC26	skin	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.0556
p.R2139Q	TCGA-A6-6781	COAD	TCGA	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.2222
p.R2139Q	DO8447	COAD	ICGC	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.2222
p.R2139Q	SIDM01588	Endometrial Carcinoma	GDSC	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.2222
p.R2139Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.2222
p.S2108Y	TCGA-AA-3977	COAD	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.0556
p.S2108Y	DO8730	COAD	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.0556
p.H798R	TCGA-AG-3891	READ	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.H798R	DO36388	READ	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.L2675V	TCGA-AG-A002	READ	TCGA	PLSTS	DEG_SPOP_SBC_1	2661:2665	Mutation rewiring degron network	0.0556
p.Q2430H	TCGA-AJ-A3IA	UCEC	TCGA	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.1667
p.Q2430H	DO43082	UCEC	ICGC	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.1667
p.T2126S	TCGA-AP-A059	UCEC	TCGA	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.25
p.T2126S	DO41361	UCEC	ICGC	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.25
p.S2146Y	TCGA-AP-A0LM	UCEC	TCGA	NTDPYSQPP	CBL_PTK	2155:2163	Mutation rewiring degron network	0.0833
p.S2146Y	DO43306	UCEC	ICGC	NTDPYSQPP	CBL_PTK	2155:2163	Mutation rewiring degron network	0.0833
p.P573H	TCGA-AP-A1DV	UCEC	TCGA	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation altering degron motif	0.6583
p.P573H	DO43186	UCEC	ICGC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation altering degron motif	0.6583
p.G722E	TCGA-AR-A0TX	BRCA	TCGA	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.2222
p.G722E	DO1663	BRCA	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.2222
p.E2426D	TCGA-AX-A0J0	UCEC	TCGA	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.0556
p.E2426D	DO41133	UCEC	ICGC	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.0556
p.P2163H	TCGA-B0-4945	KIRC	TCGA	PPGTPRPT	DEG_SCF_FBW7_1	2162:2169	Mutation altering degron motif	0.6583
p.P2163H	TCGA-B0-4945	KIRC	TCGA	NTDPYSQPP	CBL_PTK	2155:2163	Mutation altering degron motif	0.7694
p.P2163H	DO18144	KIRC	ICGC	PPGTPRPT	DEG_SCF_FBW7_1	2162:2169	Mutation altering degron motif	0.6583
p.P2163H	DO18144	KIRC	ICGC	NTDPYSQPP	CBL_PTK	2155:2163	Mutation altering degron motif	0.7694
p.S806P	TCGA-B5-A11E	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.6752
p.S806P	DO41644	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.6752
p.D2172G	TCGA-BR-4184	STAD	TCGA	DPYSQQP	CBL_PTK	2172:2178	Mutation altering degron motif	0.7198
p.D2172G	DO38328	STAD	ICGC	DPYSQQP	CBL_PTK	2172:2178	Mutation altering degron motif	0.7198
p.S802L	TCGA-BT-A3PH	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.3056
p.S802L	DO856	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.3056
p.E4114K	TCGA-C5-A7CH	CESC	TCGA	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.7022
p.E4114K	TCGA-GU-AATP	BLCA	TCGA	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.7022
p.V582I	TCGA-CA-6717	COAD	TCGA	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.25
p.V582I	DO8264	COAD	ICGC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.25
p.N2088S	TCGA-CN-A498	HNSC	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.7069
p.N2088S	DO52038	HNSC	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.7069
p.S805R	TCGA-CS-5397	LGG	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7427
p.S805R	DO22336	LGG	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7427
p.S3642C	TCGA-CV-5444	HNSC	TCGA	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.2222
p.S3642C	DO14598	HNSC	ICGC	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.2222
p.L4105V	TCGA-D1-A1O5	UCEC	TCGA	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation rewiring degron network	0.0833
p.S2095N	TCGA-D3-A2JH	SKCM	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.7069
p.S2095N	DO47263	SKCM	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.7069
p.S806F	TCGA-D3-A3ML	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7982
p.S806F	TCGA-ER-A199	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7982
p.S806F	DO47413	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7982
p.S806F	DO47395	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7982
p.P4119L	TCGA-DD-A73G	LIHC	TCGA	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.6471
p.L694F	TCGA-DK-A3IT	BLCA	TCGA	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1667
p.L694F	DO779	BLCA	ICGC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1667
p.C3992Y	TCGA-DK-AA6X	BLCA	TCGA	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.0556
p.T2170I	TCGA-DU-6392	LGG	TCGA	PPGTPRPT	DEG_SCF_FBW7_1	2162:2169	Mutation rewiring degron network	0.3056
p.T2170I	TCGA-DU-6392	LGG	TCGA	PQTPRPS	DEG_SCF_FBW7_1	2178:2184	Mutation rewiring degron network	0.1111
p.T2170I	TCGA-DU-6392	LGG	TCGA	NTDPYSQPP	CBL_PTK	2155:2163	Mutation rewiring degron network	0.1389
p.T2170I	TCGA-DU-6392	LGG	TCGA	DPYSQQP	CBL_PTK	2172:2178	Mutation rewiring degron network	0.2778
p.T2170I	DO22237	LGG	ICGC	PPGTPRPT	DEG_SCF_FBW7_1	2162:2169	Mutation rewiring degron network	0.3056
p.T2170I	DO22237	LGG	ICGC	PQTPRPS	DEG_SCF_FBW7_1	2178:2184	Mutation rewiring degron network	0.1111
p.T2170I	DO22237	LGG	ICGC	NTDPYSQPP	CBL_PTK	2155:2163	Mutation rewiring degron network	0.1389
p.T2170I	DO22237	LGG	ICGC	DPYSQQP	CBL_PTK	2172:2178	Mutation rewiring degron network	0.2778
p.P2446S	TCGA-EE-A20C	SKCM	TCGA	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.1389
p.P2446S	DO222775	MELA	ICGC	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.1389
p.P2446S	DO47665	SKCM	ICGC	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.1389
p.P4003L	TCGA-EE-A3AB	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation altering degron motif	0.6471
p.P4003S	TCGA-EE-A3AB	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation altering degron motif	0.5641
p.L2099P	TCGA-EO-A22R	UCEC	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.3056
p.L2099P	DO42713	UCEC	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.3056
p.D1845Y	TCGA-EO-A3AY	UCEC	TCGA	PPSTPTST	DEG_SCF_FBW7_1	1834:1841	Mutation rewiring degron network	0.2222
p.D1845Y	TCGA-EO-A3AY	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	1838:1842	Mutation rewiring degron network	0.25
p.D1845Y	DO43202	UCEC	ICGC	PPSTPTST	DEG_SCF_FBW7_1	1834:1841	Mutation rewiring degron network	0.2222
p.D1845Y	DO43202	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	1838:1842	Mutation rewiring degron network	0.25
p.A803D	TCGA-EO-A3AY	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7793
p.A803D	DO43202	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7793
p.S2184C	TCGA-ET-A3DU	THCA	TCGA	PQTPRPS	DEG_SCF_FBW7_1	2178:2184	Mutation altering degron motif	0.7541
p.S2184C	DO39464	THCA	ICGC	PQTPRPS	DEG_SCF_FBW7_1	2178:2184	Mutation altering degron motif	0.7541
p.R719M	TCGA-EW-A1PA	BRCA	TCGA	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.1389
p.R719M	DO5576	BRCA	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.1389
p.H798D	TCGA-FD-A3NA	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.H798D	DO602	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.D2083Y	TCGA-FS-A1Z0	SKCM	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1944
p.D2083Y	DO37431	SKCM	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1944
p.P2449L	TCGA-FS-A1ZA	SKCM	TCGA	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.0556
p.P2449L	DO37551	SKCM	ICGC	PPPY	ITCH	2436:2439	Mutation rewiring degron network	0.0556
p.P801S	TCGA-FW-A3R5	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.P801S	DO37406	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.T698I	TCGA-FW-A3R5	SKCM	TCGA	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.2778
p.T698I	DO37406	SKCM	ICGC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.2778
p.G4012A	TCGA-G2-A3IE	BLCA	TCGA	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.1667
p.I2122M	TCGA-IB-7651	PAAD	TCGA	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.1389
p.I2122M	DO46657	PAAD	ICGC	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.1389
p.P2093T	TCGA-IB-7651	PAAD	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.5919
p.P2093T	DO46657	PAAD	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.5919
p.T2078A	TCGA-IG-A3QL	ESCA	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.0556
p.D3628N	TCGA-IG-A3Y9	ESCA	TCGA	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.2222
p.E740K	TCGA-IR-A3LK	CESC	TCGA	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.0556
p.E740K	TCGA-IR-A3LK	CESC	TCGA	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.3056
p.E740K	TCGA-WS-AB45	COAD	TCGA	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.0556
p.E740K	TCGA-WS-AB45	COAD	TCGA	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.3056
p.E740K	DO44299	CESC	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.0556
p.E740K	DO44299	CESC	ICGC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.3056
p.E740K	DO51734	COAD	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.0556
p.E740K	DO51734	COAD	ICGC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.3056
p.K589N	TCGA-JX-A3Q0	CESC	TCGA	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation substituting flanking lysine	0.1667
p.K589N	DO51607	CESC	ICGC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation substituting flanking lysine	0.1667
p.S807Y	TCGA-ND-A4WC	UCS	TCGA	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.712
p.S2175G	TCGA-V9-A7HT	KIRP	TCGA	DPYSQQP	CBL_PTK	2172:2178	Mutation altering degron motif	0.6993
p.S2175G	DO219717	KIRP	ICGC	DPYSQQP	CBL_PTK	2172:2178	Mutation altering degron motif	0.6993
p.V2105M	TCGA-VQ-A8PO	STAD	TCGA	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1389
p.V2105M	DO51773	STAD	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1389
p.G4131V	DO48451	BLCA	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation rewiring degron network	0.1389
p.M3900I	DO52646	BOCA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.7618
p.S691C	DO224598	BRCA	ICGC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.0833
p.S691C	DO1010	BRCA	ICGC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.0833
p.L3897F	DO9796	COAD	ICGC	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.6981
p.P4116S	DO227549	COCA	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.6752
p.G568S	DO222492	COCA	ICGC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.2778
p.A2104V	DO222548	COCA	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1667
p.T815I	DO222842	COCA	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1111
p.A4122V	DO233652	GACA	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.6936
p.P4127S	DO52048	HNSC	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation rewiring degron network	0.25
p.S730Y	DO229348	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6009
p.S730Y	DO227504	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6009
p.S730Y	DO227496	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6009
p.S730Y	DO221548	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6009
p.S730Y	DO231171	LAML	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6009
p.H703L	DO228827	LICA	ICGC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation altering degron motif	0.7313
p.D2129E	DO228974	LICA	ICGC	DPYSQPP	CBL_PTK	2129:2135	Mutation altering degron motif	0.6758
p.P695Q	DO228976	LICA	ICGC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1944
p.T3648K	DO228986	LICA	ICGC	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.0556
p.P3898H	DO229028	LICA	ICGC	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.6583
p.P4003T	DO229026	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation altering degron motif	0.5919
p.H3993N	DO229035	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.0833
p.P2193H	DO229038	LICA	ICGC	PQTPRPS	DEG_SCF_FBW7_1	2178:2184	Mutation rewiring degron network	0.0833
p.P2436Q	DO229037	LICA	ICGC	PPPY	ITCH	2436:2439	Mutation altering degron motif	0.7035
p.P4007T	DO229045	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.3056
p.Q588H	DO229058	LICA	ICGC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.0833
p.N729D	DO50844	LIRI	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6932
p.N729D	DO45191	LIRI	ICGC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6932
p.H3993L	DO50780	LIRI	ICGC	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.0833
p.G4000R	DO45096	LIRI	ICGC	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.2778
p.Q4005H	DO51193	LUAD	ICGC	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation altering degron motif	0.7582
p.E746Q	DO230535	LUSC	ICGC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.6744
p.T744A	DO230538	LUSC	ICGC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.6028
p.T744A	SIDM01608	Endometrial Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.6028
p.T744A	ACH-000990	Endometrial/Uterine Cancer	CCLE	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.6028
p.N2088I	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.728
p.Y2094F	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.7528
p.Y2145C	DO27779	MALY	ICGC	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.0556
p.Y2145C	DO27779	MALY	ICGC	NTDPYSQPP	CBL_PTK	2155:2163	Mutation rewiring degron network	0.0556
p.S2095G	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6993
p.N2106I	DO27779	MALY	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.1111
p.L2099F	DO222363	MELA	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.3056
p.R4133T	DO222423	MELA	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation rewiring degron network	0.0833
p.R4133T	DO37425	SKCM	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation rewiring degron network	0.0833
p.L804V	DO50723	ORCA	ICGC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.5654
p.L804V	HSC-39	stomach	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.5654
p.L804V	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.5654
p.L804V	GA-10	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.5654
p.L804V	ATN-1	haematopoietic and lymphoid tissue	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.5654
p.P4007S	DO28422	OV	ICGC	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.3056
p.T2100S	DO229584	PRAD	ICGC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation rewiring degron network	0.2778
p.A3909V	DO36388	READ	ICGC	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation rewiring degron network	0.1667
p.H3910R	DO37495	SKCM	ICGC	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation rewiring degron network	0.1389
p.S4107L	DO37931	SKCM	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation rewiring degron network	0.1389
p.F4121S	DO223282	UCEC	ICGC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.7982
p.M796V	SIDM01278	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.M741T	SIDM00437	Acute Myeloid Leukemia	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7423
p.M741T	SIDM00290	Gastric Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7423
p.M741T	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7423
p.M741T	HGC-27	stomach	COSMIC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7423
p.D2092V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6674
p.D2092V	SIDM00863	Burkitt's Lymphoma	GDSC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6674
p.D2092V	SIDM00808	Burkitt's Lymphoma	GDSC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6674
p.D2092V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6674
p.D2092V	SIDM01254	Burkitt's Lymphoma	GDSC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.6674
p.A803P	SIDM00960	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.6392
p.E725K	SIDM00781	Colorectal Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.3056
p.E725K	SIDM00780	Colorectal Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.3056
p.E725K	ACH-000967	Colon/Colorectal Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.3056
p.E725K	ACH-001199	Colon/Colorectal Cancer	CCLE	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.3056
p.E725K	SNU-C2B	large intestine	COSMIC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.3056
p.S730F	SIDM00127	Oral Cavity Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6871
p.S730F	JHU-022	upper aerodigestive tract	COSMIC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation altering degron motif	0.6871
p.P2093S	SIDM01175	Other Sarcomas	GDSC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.5641
p.P2093S	ACH-002309	Sarcoma	CCLE	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.5641
p.P2093S	SW684	soft tissue	COSMIC	NQSNDPYSQPP	CBL_PTK	2088:2098	Mutation altering degron motif	0.5641
p.P813S	SIDM00367	Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1667
p.P743L	SIDM00607	Glioblastoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7582
p.P743L	SIDM00566	Oral Cavity Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7582
p.P743L	SIDM00241	Breast Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7582
p.P743L	SIDM01578	Bladder Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation altering degron motif	0.7582
p.M737V	SIDM01638	Non-Cancerous	GDSC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.1389
p.M737V	SIDM01638	Non-Cancerous	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.2222
p.M737V	SIDM00172	Head and Neck Carcinoma	GDSC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.1389
p.M737V	SIDM00172	Head and Neck Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.2222
p.E705V	SIDM00293	Small Cell Lung Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation altering degron motif	0.7693
p.E705V	ACH-002052	Lung Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation altering degron motif	0.7693
p.E705V	LU-139	lung	COSMIC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation altering degron motif	0.7693
p.V4115F	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.5957
p.V4115F	ACH-000666	Lung Cancer	CCLE	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.5957
p.V4115F	NCI-H1355	lung	COSMIC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.5957
p.A561T	SIDM00282	Colorectal Carcinoma	GDSC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.0833
p.A561T	ACH-000998	Colon/Colorectal Cancer	CCLE	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.0833
p.A561T	CW-2	large intestine	COSMIC	ESTPGIVPDA	DEG_COP1_1	570:579	Mutation rewiring degron network	0.0833
p.P2166S	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PPGTPRPT	DEG_SCF_FBW7_1	2162:2169	Mutation altering degron motif	0.6752
p.P2166S	ACH-002211	Leukemia	CCLE	PPGTPRPT	DEG_SCF_FBW7_1	2162:2169	Mutation altering degron motif	0.6752
p.P2166S	BALL-1	haematopoietic and lymphoid tissue	COSMIC	PPGTPRPT	DEG_SCF_FBW7_1	2162:2169	Mutation altering degron motif	0.6752
p.T693A	SIDM00487	Colorectal Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1389
p.T693A	ACH-000963	Colon/Colorectal Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1389
p.T693A	CCK-81	large intestine	COSMIC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1389
p.C748F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.2778
p.M796I	SIDM00837	Colorectal Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.M796I	ACH-000958	Colon/Colorectal Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.M796I	SW48	large intestine	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.E712G	SIDM00217	Colorectal Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1389
p.E712G	ACH-000999	Colon/Colorectal Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1389
p.E712G	SNU-1040	large intestine	COSMIC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation rewiring degron network	0.1389
p.I811V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2222
p.I811V	SIDM01664	Prostate Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2222
p.L2653P	SIDM00863	Burkitt's Lymphoma	GDSC	PLSTS	DEG_SPOP_SBC_1	2661:2665	Mutation rewiring degron network	0.1111
p.L2653P	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	2661:2665	Mutation rewiring degron network	0.1111
p.P1838S	SIDM00274	Gastric Carcinoma	GDSC	PPSTPTST	DEG_SCF_FBW7_1	1834:1841	Mutation altering degron motif	0.6752
p.P1838S	SIDM00274	Gastric Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	1838:1842	Mutation altering degron motif	0.6752
p.P1838S	ACH-000047	Gastric Cancer	CCLE	PPSTPTST	DEG_SCF_FBW7_1	1834:1841	Mutation altering degron motif	0.6752
p.P1838S	ACH-000047	Gastric Cancer	CCLE	PTSTS	DEG_SPOP_SBC_1	1838:1842	Mutation altering degron motif	0.6752
p.P1838S	GCIY	stomach	COSMIC	PPSTPTST	DEG_SCF_FBW7_1	1834:1841	Mutation altering degron motif	0.6752
p.P1838S	GCIY	stomach	COSMIC	PTSTS	DEG_SPOP_SBC_1	1838:1842	Mutation altering degron motif	0.6752
p.S3903F	SIDM00150	Colorectal Carcinoma	GDSC	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.7982
p.S3903F	ACH-000969	Colon/Colorectal Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.7982
p.S3903F	KM12	large intestine	COSMIC	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.7982
p.P3644S	SIDM01098	Neuroblastoma	GDSC	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.1667
p.P3644S	SK-N-SH	autonomic ganglia	COSMIC	PPTPGIS	DEG_SCF_FBW7_1	3632:3638	Mutation rewiring degron network	0.1667
p.H703Y	SIDM01664	Prostate Carcinoma	GDSC	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation altering degron motif	0.6118
p.H703Y	ACH-000952	Prostate Cancer	CCLE	VSPHEE	LIG_APCC_ABBA_1	700:705	Mutation altering degron motif	0.6118
p.T814R	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1389
p.L732H	SIDM01473	Plasma Cell Myeloma	GDSC	QKENS	DEG_APCC_KENBOX_2	726:730	Mutation rewiring degron network	0.2778
p.L732H	SIDM01473	Plasma Cell Myeloma	GDSC	MTPTIE	DEG_SCF_FBW7_2	741:746	Mutation rewiring degron network	0.0833
p.A3902G	ACH-000649	Kidney Cancer	CCLE	PPTPPAS	DEG_SCF_FBW7_1	3897:3903	Mutation altering degron motif	0.6429
p.R2139L	ACH-001029	Bone Cancer	CCLE	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.2222
p.R2139L	ACH-001034	Bone Cancer	CCLE	DPYSQPP	CBL_PTK	2129:2135	Mutation rewiring degron network	0.2222
p.S2663L	ACH-001853	Bile Duct Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	2661:2665	Mutation altering degron motif	0.7667
p.R3995P	ACH-001960	Bile Duct Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	4002:4006	Mutation rewiring degron network	0.1389
p.E2669K	ACH-002396	Bone Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	2661:2665	Mutation rewiring degron network	0.2222
p.E2669K	Sarc9371	bone	COSMIC	PLSTS	DEG_SPOP_SBC_1	2661:2665	Mutation rewiring degron network	0.2222
p.P801H	HCC-15	lung	COSMIC	ALSSS	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.V4115G	SW1088	central nervous system	COSMIC	EVSSAPDVPSM	DEG_COP1_1	4114:4124	Mutation altering degron motif	0.6421

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KMT2C

UniProt ID: Q8NEZ4

Entrez ID: 58508

Protein name: Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KMT2C in