DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SCF_FBW7_1

Location: 1834:1841

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 91.275

COIL: 0.963

CONS_SCORE: 0.4483

DSS_SCORE: 0.7242

HELIX: 0.0176

FCONS_SCORE: 1.186

RIG_SCORE: 0.525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1839M	TCGA-A5-A0G2	UCEC	TCGA	PPSTPTST	DEG_SCF_FBW7_1	0.6312
p.T1839M	DO41235	UCEC	ICGC	PPSTPTST	DEG_SCF_FBW7_1	0.6312
p.D1845Y	TCGA-EO-A3AY	UCEC	TCGA	PPSTPTST	DEG_SCF_FBW7_1	0.2222
p.D1845Y	DO43202	UCEC	ICGC	PPSTPTST	DEG_SCF_FBW7_1	0.2222
p.P1838S	SIDM00274	Gastric Carcinoma	GDSC	PPSTPTST	DEG_SCF_FBW7_1	0.6752
p.P1838S	ACH-000047	Gastric Cancer	CCLE	PPSTPTST	DEG_SCF_FBW7_1	0.6752
p.P1838S	GCIY	stomach	COSMIC	PPSTPTST	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SCF_FBW7_1	1834:1841	PPSTPTST	FBXW7	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons