DegronMD

Uniprot ID: Q8NEZ4

Source protein: Histone-lysine N-methyltransferase 2C

Source gene: KMT2C

Class: DEG_SPOP_SBC_1

Location: 4002:4006

E3 ligase: SPOP

DEGRON score: 0.603

ASA_SCORE: 31.04

COIL: 0.6462

CONS_SCORE: 0.4356

DSS_SCORE: 0.6488

HELIX: 0.038

FCONS_SCORE: 1.0942

RIG_SCORE: 0.5975

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q4005H	DO51193	LUAD	ICGC	VPSSS	DEG_SPOP_SBC_1	0.7582
p.P4003L	TCGA-EE-A3AB	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.6471
p.P4003T	DO229026	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.5919
p.P4003S	TCGA-EE-A3AB	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	0.5641
p.P4007T	DO229045	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.3056
p.P4007S	DO28422	OV	ICGC	VPSSS	DEG_SPOP_SBC_1	0.3056
p.G4000R	DO45096	LIRI	ICGC	VPSSS	DEG_SPOP_SBC_1	0.2778
p.G4012A	TCGA-G2-A3IE	BLCA	TCGA	VPSSS	DEG_SPOP_SBC_1	0.1667
p.R3995P	ACH-001960	Bile Duct Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	0.1389
p.H3993N	DO229035	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.H3993L	DO50780	LIRI	ICGC	VPSSS	DEG_SPOP_SBC_1	0.0833
p.C3992Y	TCGA-DK-AA6X	BLCA	TCGA	VPSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 12 of 12 entries

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Drug responses associated with KMT2C mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VPSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1219:1223	VPSSS	SPOP	0.9215	More...
O60238	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	DEG_SPOP_SBC_1	60:64	VPSSS	SPOP	0.9969	More...
Q96CF2	Charged multivesicular body protein 4c	DEG_SPOP_SBC_1	188:192	VPSSS	SPOP	0.9968	More...
Q6ZU64	Cilia- and flagella-associated protein 65	DEG_SPOP_SBC_1	1733:1737	VPSSS	SPOP	0.9924	More...
Q15517	Corneodesmosin	DEG_SPOP_SBC_1	398:402	VPSSS	SPOP	0.9779	More...
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DEG_SPOP_SBC_1	403:407	VPSSS	SPOP	0.9934	More...
Q9H2F5	Enhancer of polycomb homolog 1	DEG_SPOP_SBC_1	802:806	VPSSS	SPOP	0.9538	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	894:898	VPSSS	SPOP	0.9972	More...
O60353	Frizzled-6	DEG_SPOP_SBC_1	671:675	VPSSS	SPOP	0.997	More...
Q9Y5Q9	General transcription factor 3C polypeptide 3	DEG_SPOP_SBC_1	53:57	VPSSS	SPOP	0.9944	More...
Q04756	Hepatocyte growth factor activator	DEG_SPOP_SBC_1	90:94	VPSSS	SPOP	0.9524	More...
P20823	Hepatocyte nuclear factor 1-alpha	DEG_SPOP_SBC_1	333:337	VPSSS	SPOP	0.9824	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	4002:4006	VPSSS	SPOP	0.603	More...
O14529	Homeobox protein cut-like 2	DEG_SPOP_SBC_1	1413:1417	VPSSS	SPOP	0.9369	More...
Q8N9C0	Immunoglobulin superfamily member 22	DEG_SPOP_SBC_1	788:792	VPSSS	SPOP	0.9873	More...
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_SPOP_SBC_1	424:428	VPSSS	SPOP	0.9587	More...
Q8NI35	InaD-like protein	DEG_SPOP_SBC_1	1335:1339	VPSSS	SPOP	0.9943	More...
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	36:40	VPSSS	SPOP	0.9447	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4894:4898	VPSSS	SPOP	0.9445	More...
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SPOP_SBC_1	1466:1470	VPSSS	SPOP	0.9135	More...
Q5JRX3	Presequence protease, mitochondrial	DEG_SPOP_SBC_1	822:826	VPSSS	SPOP	0.8258	More...
Q3B8N5	Prospero homeobox protein 2	DEG_SPOP_SBC_1	45:49	VPSSS	SPOP	0.9929	More...
Q6DHV5	Protein CC2D2B	DEG_SPOP_SBC_1	173:177	VPSSS	SPOP	0.9766	More...
Q5JWR5	Protein dopey-1	DEG_SPOP_SBC_1	904:908	VPSSS	SPOP	0.6091	More...
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	452:456	VPSSS	SPOP	0.9261	More...

Showing 1 to 25 of 42 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPSSS

Degron related mutations and impact score

Drug responses associated with KMT2C mutations

All proteins holding degron of VPSSS