DegronMD - Q9Y5Q9(GTF3C3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M264I	TCGA-05-4396	LUAD	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0556
p.M264I	DO23838	LUAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0556
p.L281F	TCGA-36-2539	OV	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.6981
p.R276H	TCGA-A6-5661	COAD	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7133
p.R276H	TCGA-EO-A22R	UCEC	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7133
p.R276H	TCGA-L5-A43J	ESCA	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7133
p.R276H	TCGA-VQ-A8P2	STAD	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7133
p.R276H	DO8634	COAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7133
p.R276H	DO51761	STAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7133
p.R276H	DO42713	UCEC	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7133
p.E52K	TCGA-AO-A0JM	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.3056
p.E52K	DO5626	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.3056
p.E287K	TCGA-B5-A1MR	UCEC	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1944
p.E287K	DO41758	UCEC	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1944
p.G265C	TCGA-BF-A1Q0	SKCM	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0833
p.G265C	DO47374	SKCM	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0833
p.A270V	TCGA-D1-A160	UCEC	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2222
p.A270V	DO41626	UCEC	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2222
p.A270D	DO227646	COCA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2222
p.L292P	DO222755	COCA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0556
p.R276C	DO234316	ESAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.719
p.Q291K	DO229018	LICA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0833
p.N279K	DO229035	LICA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.5806
p.S282Y	DO229009	LICA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.712
p.V53A	DO45273	LIRI	ICGC	VPSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.5825
p.P48L	SIDM00545	Melanoma	GDSC	VPSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1944
p.P48L	ACH-000987	Skin Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1944
p.P48L	Mewo	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1944
p.S284F	ACH-001395	Breast Cancer	CCLE	YRRILNLLS	DEG_APCC_DBOX_1	274:282	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for GTF3C3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GTF3C3

UniProt ID: Q9Y5Q9

Entrez ID: 9330

Protein name: General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GTF3C3 in