DegronMD

Uniprot ID: Q9Y5Q9

Source protein: General transcription factor 3C polypeptide 3

Source gene: GTF3C3

Class: DEG_APCC_DBOX_1

Location: 274:282

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7415

ASA_SCORE: 46.7111

COIL: 0.314

CONS_SCORE: 0.4202

DSS_SCORE: 0.2701

HELIX: 0.6829

FCONS_SCORE: 1.2344

RIG_SCORE: 0.8144

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M264I	TCGA-05-4396	LUAD	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.0556
p.M264I	DO23838	LUAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.0556
p.L281F	TCGA-36-2539	OV	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.6981
p.R276H	TCGA-A6-5661	COAD	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.7133
p.R276H	TCGA-EO-A22R	UCEC	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.7133
p.R276H	TCGA-L5-A43J	ESCA	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.7133
p.R276H	TCGA-VQ-A8P2	STAD	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.7133
p.R276H	DO8634	COAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.7133
p.R276H	DO51761	STAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.7133
p.R276H	DO42713	UCEC	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.7133
p.E287K	TCGA-B5-A1MR	UCEC	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.1944
p.E287K	DO41758	UCEC	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.1944
p.G265C	TCGA-BF-A1Q0	SKCM	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.0833
p.G265C	DO47374	SKCM	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.0833
p.A270V	TCGA-D1-A160	UCEC	TCGA	YRRILNLLS	DEG_APCC_DBOX_1	0.2222
p.A270V	DO41626	UCEC	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.2222
p.A270D	DO227646	COCA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.2222
p.L292P	DO222755	COCA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.0556
p.R276C	DO234316	ESAD	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.719
p.Q291K	DO229018	LICA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.0833
p.N279K	DO229035	LICA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.5806
p.S282Y	DO229009	LICA	ICGC	YRRILNLLS	DEG_APCC_DBOX_1	0.712
p.S284F	ACH-001395	Breast Cancer	CCLE	YRRILNLLS	DEG_APCC_DBOX_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5Q9	General transcription factor 3C polypeptide 3	DEG_APCC_DBOX_1	274:282	YRRILNLLS	APC,CDC20,FZR1	0.7415	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons