DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
YRRILNLLS
Uniprot ID:
Q9Y5Q9
Source protein:
General transcription factor 3C polypeptide 3
Source gene:
GTF3C3
Class:
DEG_APCC_DBOX_1
Location:
274:282
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7415
ASA_SCORE:
46.7111
COIL:
0.314
CONS_SCORE:
0.4202
DSS_SCORE:
0.2701
HELIX:
0.6829
FCONS_SCORE:
1.2344
RIG_SCORE:
0.8144
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S284F
ACH-001395
Breast Cancer
CCLE
YRRILNLLS
DEG_APCC_DBOX_1
0.7222
p.R276C
DO234316
ESAD
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.719
p.R276H
TCGA-A6-5661
COAD
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.7133
p.R276H
TCGA-EO-A22R
UCEC
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.7133
p.R276H
TCGA-L5-A43J
ESCA
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.7133
p.R276H
TCGA-VQ-A8P2
STAD
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.7133
p.R276H
DO8634
COAD
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.7133
p.R276H
DO51761
STAD
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.7133
p.R276H
DO42713
UCEC
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.7133
p.S282Y
DO229009
LICA
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.712
p.L281F
TCGA-36-2539
OV
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.6981
p.N279K
DO229035
LICA
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.5806
p.A270V
TCGA-D1-A160
UCEC
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.2222
p.A270V
DO41626
UCEC
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.2222
p.A270D
DO227646
COCA
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.2222
p.E287K
TCGA-B5-A1MR
UCEC
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.1944
p.E287K
DO41758
UCEC
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.1944
p.G265C
TCGA-BF-A1Q0
SKCM
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.0833
p.G265C
DO47374
SKCM
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.0833
p.Q291K
DO229018
LICA
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.0833
p.M264I
TCGA-05-4396
LUAD
TCGA
YRRILNLLS
DEG_APCC_DBOX_1
0.0556
p.M264I
DO23838
LUAD
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.0556
p.L292P
DO222755
COCA
ICGC
YRRILNLLS
DEG_APCC_DBOX_1
0.0556
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Drug responses associated with GTF3C3 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of YRRILNLLS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y5Q9
General transcription factor 3C polypeptide 3
DEG_APCC_DBOX_1
274:282
YRRILNLLS
APC,CDC20,FZR1
0.7415
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