DegronMD - Q14872(MTF1)

FUNCTION: Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). {ECO:0000250|UniProtKB:Q07243, ECO:0000269|PubMed:8065932}.

GO - Biological processes (BP): cartilage homeostasis [GO:1990079]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cadmium ion [GO:0046686]... View more >>

GO - Molecular function (MF): cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-spec... View more >>

GO - Cellular component (CC): cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S38F	TCGA-EE-A3AG	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S38F	TCGA-QB-AA9O	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S38F	DO37471	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S38F	DO51267	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S687L	TCGA-AR-A2LE	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7667
p.S687L	DO1932	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7667
p.S38Y	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.712
p.S38Y	ACH-001642	Lymphoma	CCLE	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.712
p.S38Y	SCC-3	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.712
p.P522Q	DO228976	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation altering degron motif	0.7035
p.V36L	SIDM00770	Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.6765
p.V36L	ACH-000559	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.6765
p.V36L	NCI-H1836	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.6765
p.K32N	SIDM00845	Burkitt's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation substituting flanking lysine	0.3333
p.K32E	SIDM00845	Burkitt's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation substituting flanking lysine	0.3333
p.E527K	TCGA-MT-A67D	HNSC	TCGA	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.3056
p.E527K	DO49064	HNSC	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.3056
p.P528T	SIDM00955	Melanoma	GDSC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778
p.P528T	ACH-000812	Skin Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778
p.P528T	COLO-783	skin	COSMIC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 37 entries

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Kaplan plot for MTF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTF1

UniProt ID: Q14872

Entrez ID: 4520

Protein name: Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTF1 in