DegronMD - Q14872(MTF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A531V	TCGA-19-5956	GBM	TCGA	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1944
p.A531V	DO13863	GBM	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1944
p.S514L	TCGA-5P-A9K2	KIRP	TCGA	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1111
p.S514L	DO223947	KIRP	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1111
p.S687L	TCGA-AR-A2LE	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7667
p.S687L	DO1932	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7667
p.M532I	TCGA-EE-A20F	SKCM	TCGA	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1667
p.M532I	DO37961	SKCM	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1667
p.S38F	TCGA-EE-A3AG	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S38F	TCGA-QB-AA9O	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S38F	DO37471	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S38F	DO51267	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.Q534H	TCGA-FD-A62P	BLCA	TCGA	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1111
p.Q534H	DO44054	BLCA	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1111
p.R28K	TCGA-MN-A4N4	LUAD	TCGA	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1111
p.R28K	DO26250	LUAD	ICGC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1111
p.E527K	TCGA-MT-A67D	HNSC	TCGA	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.3056
p.E527K	DO49064	HNSC	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.3056
p.P530Q	TCGA-QK-A6VC	HNSC	TCGA	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2222
p.P530Q	DO219056	HNSC	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2222
p.T48A	DO227987	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1111
p.A517E	DO228952	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.1944
p.P522Q	DO228976	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation altering degron motif	0.7035
p.M26I	DO27935	ORCA	ICGC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.S693F	DO49202	PACA	ICGC	PGSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1944
p.P528T	SIDM00955	Melanoma	GDSC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778
p.P528T	ACH-000812	Skin Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778
p.P528T	COLO-783	skin	COSMIC	PQSTT	DEG_SPOP_SBC_1	522:526	Mutation rewiring degron network	0.2778
p.V36L	SIDM00770	Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.6765
p.V36L	ACH-000559	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.6765
p.V36L	NCI-H1836	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.6765
p.K32N	SIDM00845	Burkitt's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation substituting flanking lysine	0.3333
p.K32E	SIDM00845	Burkitt's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation substituting flanking lysine	0.3333
p.S38Y	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.712
p.S38Y	ACH-001642	Lymphoma	CCLE	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.712
p.S38Y	SCC-3	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.712
p.P692H	ACH-000041	Bone Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2222

Kaplan plot for MTF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTF1

UniProt ID: Q14872

Entrez ID: 4520

Protein name: Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTF1 in