DegronMD

Uniprot ID: Q14872

Source protein: Metal regulatory transcription factor 1

Source gene: MTF1

Class: DEG_SPOP_SBC_1

Location: 522:526

E3 ligase: SPOP

DEGRON score: 0.9444

ASA_SCORE: 79.9

COIL: 0.841

CONS_SCORE: 0.3989

DSS_SCORE: 0.4623

HELIX: 0.0314

FCONS_SCORE: 1.0118

RIG_SCORE: 0.6398

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A531V	TCGA-19-5956	GBM	TCGA	PQSTT	DEG_SPOP_SBC_1	0.1944
p.A531V	DO13863	GBM	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1944
p.S514L	TCGA-5P-A9K2	KIRP	TCGA	PQSTT	DEG_SPOP_SBC_1	0.1111
p.S514L	DO223947	KIRP	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1111
p.M532I	TCGA-EE-A20F	SKCM	TCGA	PQSTT	DEG_SPOP_SBC_1	0.1667
p.M532I	DO37961	SKCM	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1667
p.Q534H	TCGA-FD-A62P	BLCA	TCGA	PQSTT	DEG_SPOP_SBC_1	0.1111
p.Q534H	DO44054	BLCA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1111
p.E527K	TCGA-MT-A67D	HNSC	TCGA	PQSTT	DEG_SPOP_SBC_1	0.3056
p.E527K	DO49064	HNSC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.3056
p.P530Q	TCGA-QK-A6VC	HNSC	TCGA	PQSTT	DEG_SPOP_SBC_1	0.2222
p.P530Q	DO219056	HNSC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.2222
p.A517E	DO228952	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1944
p.P522Q	DO228976	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.7035
p.P528T	SIDM00955	Melanoma	GDSC	PQSTT	DEG_SPOP_SBC_1	0.2778
p.P528T	ACH-000812	Skin Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	0.2778
p.P528T	COLO-783	skin	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	522:526	PQSTT	SPOP	0.9444	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	962:966	PQSTT	SPOP	0.878	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	532:536	PQSTT	SPOP	0.9656	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	620:624	PQSTT	SPOP	0.9308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons