DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 962:966

E3 ligase: SPOP

DEGRON score: 0.878

ASA_SCORE: 92.44

COIL: 0.8958

CONS_SCORE: 0

DSS_SCORE: 0.6341

HELIX: 0.0158

FCONS_SCORE: 0

RIG_SCORE: 0.6642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R953I	TCGA-49-4488	LUAD	TCGA	PQSTT	DEG_SPOP_SBC_1	0.0833
p.R953I	DO24750	LUAD	ICGC	PQSTT	DEG_SPOP_SBC_1	0.0833
p.T976A	TCGA-56-7731	LUSC	TCGA	PQSTT	DEG_SPOP_SBC_1	0.0556
p.T976A	DO45527	LUSC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.0556
p.N952S	TCGA-ER-A19F	SKCM	TCGA	PQSTT	DEG_SPOP_SBC_1	0.0556
p.N952S	DO37679	SKCM	ICGC	PQSTT	DEG_SPOP_SBC_1	0.0556
p.S959F	TCGA-FS-A1ZC	SKCM	TCGA	PQSTT	DEG_SPOP_SBC_1	0.6944
p.S959F	DO37487	SKCM	ICGC	PQSTT	DEG_SPOP_SBC_1	0.6944
p.S971G	TCGA-GN-A268	SKCM	TCGA	PQSTT	DEG_SPOP_SBC_1	0.1944
p.S971G	DO37477	SKCM	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1944
p.K975N	TCGA-ZF-AA4V	BLCA	TCGA	PQSTT	DEG_SPOP_SBC_1	0.1944
p.K975N	DO219087	BLCA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1944
p.E969D	DO8898	COAD	ICGC	PQSTT	DEG_SPOP_SBC_1	0.25
p.T966I	DO233888	GACA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.7078
p.S964R	DO228974	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.8538
p.T966N	DO229022	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.7055
p.D958E	DO229034	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.2222
p.S971I	DO27833	MALY	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1944
p.R973K	SIDM00525	Osteosarcoma	GDSC	PQSTT	DEG_SPOP_SBC_1	0.1389
p.R973K	ACH-000359	Bone Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	0.1389
p.R973K	MG-63	bone	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.1389
p.W967G	ACH-000987	Skin Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	0.3056
p.W967G	Mewo	skin	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	522:526	PQSTT	SPOP	0.9444	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	962:966	PQSTT	SPOP	0.878	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	532:536	PQSTT	SPOP	0.9656	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	620:624	PQSTT	SPOP	0.9308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons