DegronMD

Uniprot ID: Q5T0Z8

Source protein: Uncharacterized protein C6orf132

Source gene: C6orf132

Class: DEG_SPOP_SBC_1

Location: 620:624

E3 ligase: SPOP

DEGRON score: 0.9308

ASA_SCORE: 98.8

COIL: 0.947

CONS_SCORE: 0.6166

DSS_SCORE: 0.6315

HELIX: 0.024

FCONS_SCORE: 0.9598

RIG_SCORE: 0.6698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T624N	DO228948	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.7055
p.P613H	DO45053	LINC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1389
p.L631F	DO230993	LUSC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1389
p.L631F	DO230990	LUSC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1389
p.L631F	DO231007	LUSC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	522:526	PQSTT	SPOP	0.9444	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	962:966	PQSTT	SPOP	0.878	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	532:536	PQSTT	SPOP	0.9656	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	620:624	PQSTT	SPOP	0.9308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons