DegronMD

Uniprot ID: Q9C0D7

Source protein: Probable ribonuclease ZC3H12C

Source gene: ZC3H12C

Class: DEG_SPOP_SBC_1

Location: 532:536

E3 ligase: SPOP

DEGRON score: 0.9656

ASA_SCORE: 82.78

COIL: 0.9274

CONS_SCORE: 0.3992

DSS_SCORE: 0.6362

HELIX: 0.0494

FCONS_SCORE: 0.9809

RIG_SCORE: 0.6275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P532L	TCGA-FS-A1ZZ	SKCM	TCGA	PQSTT	DEG_SPOP_SBC_1	0.7582
p.Q534E	DO228933	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.6744
p.R523I	DO229037	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.0833
p.P544S	DO229050	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1111
p.P543T	DO41361	UCEC	ICGC	PQSTT	DEG_SPOP_SBC_1	0.1389
p.S537P	SIDM00845	Burkitt's Lymphoma	GDSC	PQSTT	DEG_SPOP_SBC_1	0.3056
p.S537P	SIDM00035	Thyroid Gland Carcinoma	GDSC	PQSTT	DEG_SPOP_SBC_1	0.3056
p.S537P	SIDM00461	Acute Myeloid Leukemia	GDSC	PQSTT	DEG_SPOP_SBC_1	0.3056
p.S537P	SIDM01519	Head and Neck Carcinoma	GDSC	PQSTT	DEG_SPOP_SBC_1	0.3056
p.S537P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.3056
p.S537P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.3056
p.T536A	SIDM01611	Endometrial Carcinoma	GDSC	PQSTT	DEG_SPOP_SBC_1	0.7139
p.S538P	ACH-000037	Sarcoma	CCLE	PQSTT	DEG_SPOP_SBC_1	0.2778
p.S538P	ACH-000786	Lymphoma	CCLE	PQSTT	DEG_SPOP_SBC_1	0.2778
p.S538P	ACH-000992	Head and Neck Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	0.2778
p.S538P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.2778
p.S538P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.2778
p.T537A	ACH-000996	Endometrial/Uterine Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	0.3056
p.T536S	ACH-001558	Lung Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	0.6005
p.S530P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.2778
p.S530P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.2778
p.S530P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14872	Metal regulatory transcription factor 1	DEG_SPOP_SBC_1	522:526	PQSTT	SPOP	0.9444	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	962:966	PQSTT	SPOP	0.878	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	532:536	PQSTT	SPOP	0.9656	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	620:624	PQSTT	SPOP	0.9308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQSTT

Degron related mutations and impact score

Drug responses associated with ZC3H12C mutations

All proteins holding degron of PQSTT