DegronMD - Q9C0H5(ARHGAP39)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P301S	TCGA-21-1081	LUSC	TCGA	PPLY	ITCH	310:313	Mutation rewiring degron network	0.0833
p.P301S	DO45299	LIRI	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.0833
p.P301S	DO26930	LUSC	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.0833
p.R440L	TCGA-22-4591	LUSC	TCGA	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.0833
p.R440L	DO26620	LUSC	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.0833
p.S273T	TCGA-2W-A8YY	CESC	TCGA	PGSSS	DEG_SPOP_SBC_1	282:286	Mutation blocking phosphorylation signal	0.5278
p.S273T	DO223732	CESC	ICGC	PGSSS	DEG_SPOP_SBC_1	282:286	Mutation blocking phosphorylation signal	0.5278
p.G423S	TCGA-37-4132	LUSC	TCGA	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.5882
p.G423S	DO26528	LUSC	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.5882
p.G423S	SIDM00216	Colorectal Carcinoma	GDSC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.5882
p.G423S	ACH-000989	Colon/Colorectal Cancer	CCLE	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.5882
p.R305C	TCGA-AX-A2HD	UCEC	TCGA	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	TCGA-CG-4304	STAD	TCGA	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	DO38615	STAD	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	DO42608	UCEC	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	SIDM00217	Colorectal Carcinoma	GDSC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	SIDM01086	B-Lymphoblastic Leukemia	GDSC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	ACH-000874	Leukemia	CCLE	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	ACH-000999	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.R305C	SNU-1040	large intestine	COSMIC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1944
p.E314K	TCGA-CG-5728	STAD	TCGA	PPLY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.E314K	DO38619	STAD	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.V679I	TCGA-CV-7183	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.2778
p.V679I	DO15695	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.2778
p.V679I	DO229094	UTCA	ICGC	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.2778
p.S428F	TCGA-D3-A2JL	SKCM	TCGA	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.7982
p.S428F	DO47278	SKCM	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.7982
p.P304L	TCGA-D9-A1JW	SKCM	TCGA	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1667
p.P304L	DO37786	SKCM	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1667
p.S303F	TCGA-DD-A39V	LIHC	TCGA	PPLY	ITCH	310:313	Mutation blocking phosphorylation signal	0.5833
p.S303F	DO44990	LIHC	ICGC	PPLY	ITCH	310:313	Mutation blocking phosphorylation signal	0.5833
p.P674L	TCGA-EE-A20H	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation altering degron motif	0.6471
p.P674L	DO37986	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation altering degron motif	0.6471
p.E180K	TCGA-EK-A3GK	CESC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.E180K	DO49964	CESC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.S426L	TCGA-FS-A4F9	SKCM	TCGA	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.6556
p.S426L	DO38069	SKCM	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.6556
p.S302Y	TCGA-K4-A54R	BLCA	TCGA	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1111
p.S302Y	DO48611	BLCA	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1111
p.E180Q	TCGA-QK-A6IG	HNSC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.E180Q	DO50002	HNSC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.E180Q	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.E180Q	ACH-002215	Lymphoma	CCLE	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.E180Q	BC-3	haematopoietic and lymphoid tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.R686C	TCGA-VQ-A91D	STAD	TCGA	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.0833
p.R686C	DO51783	STAD	ICGC	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.0833
p.R686C	ACH-000999	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.0833
p.P304S	TCGA-W3-A825	SKCM	TCGA	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1667
p.P304S	DO51272	SKCM	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1667
p.A161E	TCGA-XF-A9SY	BLCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.A161E	DO51918	BLCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.1389
p.P311L	DO225108	BRCA	ICGC	PPLY	ITCH	310:313	Mutation altering degron motif	0.7582
p.P311L	ACH-000870	Lung Cancer	CCLE	PPLY	ITCH	310:313	Mutation altering degron motif	0.7582
p.Y418H	DO228246	BRCA	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.25
p.P323H	DO222817	BTCA	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.0556
p.A322V	DO230315	COCA	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.0833
p.Y320C	DO233272	GACA	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.1389
p.G425D	DO233613	GACA	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.6087
p.A419V	DO233888	GACA	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.2778
p.R411C	DO233855	GACA	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.0556
p.P323L	DO11854	GBM	ICGC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.0556
p.E664D	DO14566	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.0833
p.D182E	DO229022	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	168:173	Mutation rewiring degron network	0.0833
p.S671N	DO50913	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation rewiring degron network	0.2778
p.P287S	DO220886	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.P422L	DO220890	MELA	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.6471
p.S676Y	DO31150	OV	ICGC	VPSSS	DEG_SPOP_SBC_1	673:677	Mutation altering degron motif	0.712
p.K294N	DO32904	PACA	ICGC	PGSSS	DEG_SPOP_SBC_1	282:286	Mutation substituting flanking lysine	0.2222
p.R415Q	DO229542	UTCA	ICGC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.1667
p.G424S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation altering degron motif	0.5882
p.E314A	SIDM00695	Melanoma	GDSC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.E314A	ACH-000322	Skin Cancer	CCLE	PPLY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.E314A	HT-144	skin	COSMIC	PPLY	ITCH	310:313	Mutation rewiring degron network	0.3056
p.Y418C	SIDM01045	Endometrial Carcinoma	GDSC	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.25
p.Y418C	ACH-000978	Endometrial/Uterine Cancer	CCLE	NPGGGSYSLQP	CBL_PTK	421:431	Mutation rewiring degron network	0.25
p.P287A	SIDM00875	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.P287A	HCC1806	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.S432N	ACH-000893	Lung Cancer	CCLE	NPGGGSYSLQP	CBL_PTK	421:431	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP39

UniProt ID: Q9C0H5

Entrez ID: 80728

Protein name: Rho GTPase-activating protein 39

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP39 in