DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSGSSS
Uniprot ID:
Q9C0H5
Source protein:
Rho GTPase-activating protein 39
Source gene:
ARHGAP39
Class:
DEG_SCF_TRCP1_1
Location:
168:173
E3 ligase:
BTRC
DEGRON score:
0.9988
ASA_SCORE:
73.0333
COIL:
0.9498
CONS_SCORE:
0.3446
DSS_SCORE:
0.535
HELIX:
0.0323
FCONS_SCORE:
1.0647
RIG_SCORE:
0.5714
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E180K
TCGA-EK-A3GK
CESC
TCGA
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.E180K
DO49964
CESC
ICGC
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.E180Q
TCGA-QK-A6IG
HNSC
TCGA
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.E180Q
DO50002
HNSC
ICGC
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.E180Q
SIDM00895
B-Cell Non-Hodgkin's Lymphoma
GDSC
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.E180Q
ACH-002215
Lymphoma
CCLE
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.E180Q
BC-3
haematopoietic_and_lymphoid_tissue
COSMIC
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.A161E
TCGA-XF-A9SY
BLCA
TCGA
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.A161E
DO51918
BLCA
ICGC
DSGSSS
DEG_SCF_TRCP1_1
0.1389
p.D182E
DO229022
LICA
ICGC
DSGSSS
DEG_SCF_TRCP1_1
0.0833
Drug responses associated with ARHGAP39 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13428
Treacle protein
DEG_SCF_TRCP1_1
931:936
DSGSSS
BTRC
0.9956
More...
Q8IYG6
Leucine-rich repeat-containing protein 56
DEG_SCF_TRCP1_1
460:465
DSGSSS
BTRC
0.9835
More...
Q96S38
Ribosomal protein S6 kinase delta-1
DEG_SCF_TRCP1_1
499:504
DSGSSS
BTRC
0.9876
More...
Q9C0H9
SRC kinase signaling inhibitor 1
DEG_SCF_TRCP1_1
512:517
DSGSSS
BTRC
0.9672
More...
Q9H7S9
Zinc finger protein 703
DEG_SCF_TRCP1_1
169:174
DSGSSS
BTRC
0.9995
More...
Q9NQ76
Matrix extracellular phosphoglycoprotein
DEG_SCF_TRCP1_1
515:520
DSGSSS
BTRC
0.9943
More...
Q9Y4G8
Rap guanine nucleotide exchange factor 2
DEG_SCF_TRCP1_1
53:58
DSGSSS
BTRC
0.9394
More...
Q9C0H5
Rho GTPase-activating protein 39
DEG_SCF_TRCP1_1
168:173
DSGSSS
BTRC
0.9988
More...
Q86VQ1
Glucocorticoid-induced transcript 1 protein
DEG_SCF_TRCP1_1
393:398
DSGSSS
BTRC
0.9577
More...