DegronMD - Q9H7S9(ZNF703)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S74T	TCGA-85-8479	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.6005
p.S74T	DO45443	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.6005
p.G348E	TCGA-EO-A22U	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	357:361	Mutation rewiring degron network	0.0833
p.G348E	DO43755	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	357:361	Mutation rewiring degron network	0.0833
p.L63F	TCGA-FD-A6TC	BLCA	TCGA	PLSST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.L63F	DO49755	BLCA	ICGC	PLSST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.S183F	TCGA-OR-A5LF	ACC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	169:174	Mutation rewiring degron network	0.0833
p.S183F	TCGA-OR-A5LF	ACC	TCGA	VSSTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.2222
p.G23S	TCGA-RC-A7S9	LIHC	TCGA	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation rewiring degron network	0.1389
p.G23S	DO52309	LIHC	ICGC	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation rewiring degron network	0.1389
p.S18G	DO227979	COCA	ICGC	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation rewiring degron network	0.2778
p.G206V	DO227987	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.P353T	DO228940	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	357:361	Mutation rewiring degron network	0.2222
p.S359I	DO229022	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	357:361	Mutation altering degron motif	0.7341
p.D165Y	DO229022	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	169:174	Mutation rewiring degron network	0.2222
p.D165Y	DO229022	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.0556
p.G164S	DO229053	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	169:174	Mutation rewiring degron network	0.1944
p.G164S	ACH-000941	Endometrial/Uterine Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	169:174	Mutation rewiring degron network	0.1944
p.G349C	DO228584	MALY	ICGC	PPSSS	DEG_SPOP_SBC_1	357:361	Mutation rewiring degron network	0.1111
p.S216L	DO232761	PBCA	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.P203L	DO219878	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.P203S	DO229234	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.P71Q	SIDM01278	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7035
p.P76S	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.P76S	ACH-000920	Leukemia	CCLE	PLSST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.P76S	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.S20G	SIDM00845	Burkitt's Lymphoma	GDSC	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation blocking phosphorylation signal	0.6667
p.S20G	SIDM00035	Thyroid Gland Carcinoma	GDSC	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation blocking phosphorylation signal	0.6667
p.S20G	ACH-000997	Colon/Colorectal Cancer	CCLE	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation blocking phosphorylation signal	0.6667
p.P204S	SIDM01120	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389
p.T178A	SIDM00280	Gastric Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	175:179	Mutation altering degron motif	0.7139
p.T178A	ACH-000560	Gastric Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	175:179	Mutation altering degron motif	0.7139
p.R26S	SIDM01217	Other Blood Cancers	GDSC	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation rewiring degron network	0.0556
p.P13L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation altering degron motif	0.7582
p.D165H	ACH-000489	Colon/Colorectal Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	169:174	Mutation rewiring degron network	0.2222
p.D165H	ACH-000489	Colon/Colorectal Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.0556
p.G19C	ACH-000900	Lung Cancer	CCLE	PRTPESS	DEG_SCF_FBW7_1	10:16	Mutation rewiring degron network	0.25
p.S359R	ACH-000960	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	357:361	Mutation altering degron motif	0.7427

Kaplan plot for ZNF703 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF703

UniProt ID: Q9H7S9

Entrez ID: 80139

Protein name: Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF703 in