DegronMD

Uniprot ID: Q9H7S9

Source protein: Zinc finger protein 703

Source gene: ZNF703

Class: DEG_SCF_FBW7_1

Location: 10:16

E3 ligase: FBXW7

DEGRON score: 0.9952

ASA_SCORE: 105.5143

COIL: 0.9517

CONS_SCORE: 0.3426

DSS_SCORE: 0.8177

HELIX: 0.0224

FCONS_SCORE: 1.055

RIG_SCORE: 0.5061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G23S	TCGA-RC-A7S9	LIHC	TCGA	PRTPESS	DEG_SCF_FBW7_1	0.1389
p.G23S	DO52309	LIHC	ICGC	PRTPESS	DEG_SCF_FBW7_1	0.1389
p.S18G	DO227979	COCA	ICGC	PRTPESS	DEG_SCF_FBW7_1	0.2778
p.S20G	SIDM00845	Burkitt's Lymphoma	GDSC	PRTPESS	DEG_SCF_FBW7_1	0.6667
p.S20G	SIDM00035	Thyroid Gland Carcinoma	GDSC	PRTPESS	DEG_SCF_FBW7_1	0.6667
p.S20G	ACH-000997	Colon/Colorectal Cancer	CCLE	PRTPESS	DEG_SCF_FBW7_1	0.6667
p.R26S	SIDM01217	Other Blood Cancers	GDSC	PRTPESS	DEG_SCF_FBW7_1	0.0556
p.P13L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PRTPESS	DEG_SCF_FBW7_1	0.7582
p.G19C	ACH-000900	Lung Cancer	CCLE	PRTPESS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7S9	Zinc finger protein 703	DEG_SCF_FBW7_1	10:16	PRTPESS	FBXW7	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons