DegronMD - Q86VQ1(GLCCI1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P16L	TCGA-77-7465	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.P16L	DO27699	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1111
p.D389V	TCGA-91-6828	LUAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.2222
p.D389V	DO26150	LUAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.2222
p.D385N	TCGA-95-7948	LUAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.1111
p.D385N	DO25133	LUAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.1111
p.S172C	TCGA-98-A53I	LUSC	TCGA	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation blocking phosphorylation signal	0.5833
p.S172C	DO219182	LUSC	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation blocking phosphorylation signal	0.5833
p.D154G	TCGA-AG-A002	READ	TCGA	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1389
p.D154G	TCGA-CA-6718	COAD	TCGA	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1389
p.D154G	DO7801	COAD	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1389
p.S172Y	TCGA-F1-6874	STAD	TCGA	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation blocking phosphorylation signal	0.5833
p.S172Y	DO38201	STAD	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation blocking phosphorylation signal	0.5833
p.Y388C	TCGA-FD-A5C0	BLCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.1944
p.Y388C	DO44046	BLCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.1944
p.Y388C	SIDM01066	Melanoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.1944
p.Y388C	ACH-000650	Skin Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.1944
p.Y388C	IGR-37	skin	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.1944
p.S165N	TCGA-IB-7651	PAAD	TCGA	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7069
p.S165N	DO46657	PAAD	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7069
p.R168K	TCGA-ZF-A9RC	BLCA	TCGA	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.R168K	DO219068	BLCA	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.R162Q	DO228050	EOPC	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6218
p.S7F	DO11854	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.9093
p.D389N	DO228965	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.2222
p.G395W	DO229015	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation altering degron motif	0.7825
p.V161F	DO229028	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7068
p.K155N	DO229022	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation substituting flanking lysine	0.2778
p.Q160E	DO23533	LIRI	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.S172F	DO222868	MELA	ICGC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation blocking phosphorylation signal	0.5833
p.R390C	DO229470	SKCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.25
p.P399Q	DO229272	THCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.3056
p.A153V	SIDM00908	Non-Cancerous	GDSC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.A153V	SIDM00909	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.A153V	SIDM00100	Mesothelioma	GDSC	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1111
p.L400F	ACH-000786	Lymphoma	CCLE	DSGSSS	DEG_SCF_TRCP1_1	393:398	Mutation rewiring degron network	0.2778
p.R162W	ACH-001068	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7523
p.Q159P	ACH-002061	Leukemia	CCLE	VRTSS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLCCI1

UniProt ID: Q86VQ1

Entrez ID: 113263

Protein name: Glucocorticoid-induced transcript 1 protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLCCI1 in