DegronMD

Uniprot ID: Q86VQ1

Source protein: Glucocorticoid-induced transcript 1 protein

Source gene: GLCCI1

Class: DEG_SPOP_SBC_1

Location: 161:165

E3 ligase: SPOP

DEGRON score: 0.7782

ASA_SCORE: 87.4

COIL: 0.8156

CONS_SCORE: 0.3444

DSS_SCORE: 0.6536

HELIX: 0.0946

FCONS_SCORE: 0.6214

RIG_SCORE: 0.6985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S172C	TCGA-98-A53I	LUSC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.5833
p.S172C	DO219182	LUSC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.5833
p.D154G	TCGA-AG-A002	READ	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1389
p.D154G	TCGA-CA-6718	COAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1389
p.D154G	DO7801	COAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.S172Y	TCGA-F1-6874	STAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.5833
p.S172Y	DO38201	STAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.5833
p.S165N	TCGA-IB-7651	PAAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.7069
p.S165N	DO46657	PAAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.7069
p.R168K	TCGA-ZF-A9RC	BLCA	TCGA	VRTSS	DEG_SPOP_SBC_1	0.25
p.R168K	DO219068	BLCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.25
p.R162Q	DO228050	EOPC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6218
p.V161F	DO229028	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.7068
p.K155N	DO229022	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.Q160E	DO23533	LIRI	ICGC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.S172F	DO222868	MELA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.5833
p.A153V	SIDM00908	Non-Cancerous	GDSC	VRTSS	DEG_SPOP_SBC_1	0.1111
p.A153V	SIDM00909	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.1111
p.A153V	SIDM00100	Mesothelioma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.1111
p.R162W	ACH-001068	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	0.7523
p.Q159P	ACH-002061	Leukemia	CCLE	VRTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons