DegronMD

Uniprot ID: Q8WY36

Source protein: HMG box transcription factor BBX

Source gene: BBX

Class: DEG_SPOP_SBC_1

Location: 511:515

E3 ligase: SPOP

DEGRON score: 0.9823

ASA_SCORE: 92.06

COIL: 0.8224

CONS_SCORE: 0.3494

DSS_SCORE: 0.6101

HELIX: 0.0556

FCONS_SCORE: 1.0309

RIG_SCORE: 0.6724

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R512C	TCGA-59-2349	OV	TCGA	VRTSS	DEG_SPOP_SBC_1	0.719
p.R512C	DO28621	OV	ICGC	VRTSS	DEG_SPOP_SBC_1	0.719
p.R512C	SIDM00392	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.719
p.R512C	ACH-000810	Skin Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.719
p.R512C	SK-MEL-30	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.719
p.S516C	TCGA-86-8585	LUAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.3056
p.S516C	DO24850	LUAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.S516N	TCGA-86-8585	LUAD	TCGA	VRTSS	DEG_SPOP_SBC_1	0.3056
p.S516N	DO24850	LUAD	ICGC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.E501Q	TCGA-BA-4077	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.0556
p.E501Q	DO1146	BRCA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.E501Q	DO15647	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.0556
p.D505H	TCGA-BA-4077	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1667
p.D505H	DO15647	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1667
p.L522F	TCGA-BA-4077	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	0.1389
p.L522F	DO15647	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	0.1389
p.P507S	TCGA-FR-A726	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	0.2222
p.P507S	DO48665	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2222
p.G506E	DO22295	LGG	ICGC	VRTSS	DEG_SPOP_SBC_1	0.6389
p.G506E	ACH-000786	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	0.6389
p.Y507C	DO44714	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	0.2222
p.K525N	SIDM02039	Colorectal Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.1667
p.R508C	SIDM00290	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.25
p.R508C	ACH-000847	Gastric Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.25
p.R508C	HGC-27	stomach	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.25
p.Q502L	ACH-000786	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	0.5278
p.E511G	ACH-000985	Colon/Colorectal Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.7199
p.E511G	LS-411N	large_intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.7199
p.A505V	ACH-001517	Endometrial/Uterine Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.1667
p.A505V	HEC-1	endometrium	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.1667
p.M515R	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTSS

Degron related mutations and impact score

Drug responses associated with BBX mutations

All proteins holding degron of VRTSS