DegronMD

Uniprot ID: Q9BY84

Source protein: Dual specificity protein phosphatase 16

Source gene: DUSP16

Class: DEG_SPOP_SBC_1

Location: 487:491

E3 ligase: SPOP

DEGRON score: 0.7285

ASA_SCORE: 97.6

COIL: 0.9032

CONS_SCORE: 0.2014

DSS_SCORE: 0.6475

HELIX: 0.0372

FCONS_SCORE: 0.9267

RIG_SCORE: 0.6123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H485R	SIDM00128	Head and Neck Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.H485R	ACH-002249	Head and Neck Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	0.2778
p.H485R	JHU-011	upper_aerodigestive_tract	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.2778
p.S486L	SIDM00475	Ovarian Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.S486L	SIDM01134	Small Cell Lung Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.S486L	OV-56	ovary	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.3056
p.S486L	NCI-H841	lung	COSMIC	VRTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13439	Golgin subfamily A member 4	DEG_SPOP_SBC_1	94:98	VRTSS	SPOP	0.9897	More...
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B	DEG_SPOP_SBC_1	376:380	VRTSS	SPOP	0.996	More...
Q8TDG4	Helicase POLQ-like	DEG_SPOP_SBC_1	253:257	VRTSS	SPOP	0.5893	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9817:9821	VRTSS	SPOP	0.8575	More...
Q8WY36	HMG box transcription factor BBX	DEG_SPOP_SBC_1	511:515	VRTSS	SPOP	0.9823	More...
Q9BY84	Dual specificity protein phosphatase 16	DEG_SPOP_SBC_1	487:491	VRTSS	SPOP	0.7285	More...
Q8TE59	A disintegrin and metalloproteinase with thrombospondin motifs 19	DEG_SPOP_SBC_1	702:706	VRTSS	SPOP	0.6468	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	310:314	VRTSS	SPOP	0.9965	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	161:165	VRTSS	SPOP	0.7782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons